最新刊期
      卷 0 ， 期 0 ， 2020
      • CHENG Bingbing1 LIU Honglin1 ZHANG Guobin1 LUO Shaofeng2 PENG Xiaohui2 TENG Maikun2 WEI Shiqiang1 1
        Issue 3, (2008)
        摘要：Human phosphoribosylpyrophosphate synthetase (hPRS1) is an important metabolite essential for nucleo-tide synthesis. The second level structures of hPRS1 before and after binding different reactants were investigated by synchrotron radiation circular dichroism (SRCD) spectroscopy. The results show that the second level structures of hPRS1 after binding reactants possess elasticity and change obviously following the outside factors. The study indi-cates that the transform of second level structures in hPRS1 is necessary for its function.  
        关键词：hPRS1;Circular dichroism spectroscopy;SRCD;Second level structure   
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        发布时间：2021-03-12
      • LIANG Jingqiu1 HUANG Xinhua1,2 LE Zichun3 LIANG Zhongzhu1 1
        Issue 3, (2008)
        摘要：Compound X-ray focusing refraction lens is a new refraction optical device for X-ray focusing and imag-ing. The development and main applications of compound X-ray focusing refraction lenses are reviewed in this paper, with emphases in their fabrication materials and structure design.  
        关键词：Compound X-ray focusing refraction lens;X-ray microbeam;Refractive focusing   
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        发布时间：2021-03-12
      • YAN Yingbing1,2 LENG Yongbin1 YANG Song1,2 1
        Issue 3, (2008)
        摘要：The paper presents an online data analysis software package, which was developed based on EPICS soft IOC and run-time database template techniques. Preliminary experiments in the Linac commissioning of SSRF (Shanghai Synchrotron Radiation Facility) showed that the package had good real-time performance, portability and extensibility. It has been one of the major toolkits for debugging, evaluation and diagnostics of beam instrumentation system.  
        关键词：EPICS;Soft IOC;Online data analysis;SSRF(Shanghai Synchrotron Radiation Facility)   
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        发布时间：2021-03-12
      • XU Shanshan1,2 YE Kairong1 CHEN Yongzhong1 1
        Issue 3, (2008)
        摘要：Emittance is an important parameter to evaluate beam quality. With the development of accelerator tech-nology, higher beam quality is demanded. Especially, for the measurement of small emittance, higher solution is re-quired. Based on measurement theory of multi-changing focusing strength, this paper discusses measurement tech-nique and measurement device of the linac of SSRF to enhance accuracy and reliability of emittance measurement, including appropriate use of thin lens, the multi-point least squares fitting, choice of cross section measuring target, and design of software measurement, etc. The stability and reproducibility of measurement results show that the ap-proach can be of significance in emittance measurement of the coming project of free electron laser.  
        关键词：Linac;Emittance measurement   
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        发布时间：2021-03-12
      • JIN Qingxiu1 TONG Dechun1 TAO Xiaokui1 YANG Jingsheng2 1
        Issue 3, (2008)
        摘要：In this paper, the design and performance characteristics of accelerating guide for C-band SW electron linac are discussed. The guide can accelerate electrons to 9 MeV or 6 MeV. Its length is about 620mm, and a Pierce electron gun has been used. A 2.5MW pulsed magnetron at 5712 MHz is served as the guide’s RF power source. The two energy modes are performed by turning RF power source and the injecting voltage of electron gun.  
        关键词：C-band SW accelerating structure;Two X-ray energy modes;High power test set-up   
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        发布时间：2021-03-12
      • LIU Ruiqin1 XIE Leidong2 SHENG Kanglong2 1
        Issue 3, (2008)
        摘要：Effect of pH value on graft yield (Yg) of 2-(dimethylamino)ethyl methacrylate (DMAEMA) onto silk fab- rics initiated by ultraviolet rays are investigated in this paper. Three kinds of grafted silk fabrics obtained in different pH adjustment processes were characterized by DSC (differential scanning calorimetry), TGA/DTG (thermogravim- etry analysis and derivative thermogravimetry, differential thermal analysis (DTA) and contact angel measurement. The thermal analysis results indicated that the grafted silk fabrics showed different compatibility between the silk fibroin molecules and 2-(dimethylamino)ethyl methacrylate polymers. And the crystalline structure of the grafted silk fabrics remained unchanged, or changed due to the pH adjustment process. It was found that the gel particles sized differently in solutions with the pH value adjusted in different ways and this might lead to different grafted effects of the silk fabrics.  
        关键词：Silk fabrics;Photo-grafting;graft copolymerization;pH   
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        发布时间：2021-03-12
      • HE Jing1,2 LI Qiang1 JIN Xiaodong1,2 1
        Issue 3, (2008)
        摘要：The work was to study hprt mutation inducted in human hepatocyte L02 cells exposed to 12C6+ ions, and to provide basic data and evidence for risk assessment of heavy ion irradiation to healthy tissues. Human hepatocyte L02 cells were irradiated with 83.6 MeV/u 12C6+ ions with LET of 30 keV/ μ m or X-rays. Survival fractions of the cells were studied by colony-formation efficiency. Mutation induction at the hprt locus was detected by measuring 6-thioguanine-resistant clones. After 10 days of incubation in presence of 15 mg/L 6-TG, the mutants were counted. The results showed that the survival fraction of L02 cells irradiated by carbon beams was much lower than that of the X-ray irradiated cells. The number of mutants per 106 surviving cells and the mutation frequency increased with the carbon ion and X-ray dose up to 1 Gy. It is concluded that human hepatocyte L02 cells are more sensitive to high-LET carbon ions, which are more effective in inducing hprt mutation in the survivors of L02 cells.  
        关键词：hprt gene;Mutation frequency;Dose-effect relationship;Heavy ions   
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        发布时间：2021-03-12
      • LI Peirui1,2 YAN Shiliang1 ZHANG Donghui1 LI Zongyi2 QIN Guangyong1 HUO Yuping1 1
        Issue 3, (2008)
        摘要：The bacteria of bioflocculant-producing Brevundimonas sp.FJ-7 was implanted by 30 keV N+ ions to a doses of 5×1014 ～1×1016 ions·cm-2. Mutagenic effects of the microbe were studied. The results indicated that the survival rates exhibited a saddle-like curve and the mutagenic effects of N+ ion implantation were unique. A high genetic stability and flocculating activity mutant strain, NIM-192 was screened out, with a dose of 5×1015 ions·cm-2. Fermentation curve of bioflocculant-producing showed the growing speed of NIM-192 was slower, but the flocculating activity was higher than the original one, and the flocculating rate of NIM-192 increased by 34.26%. This indicated that biological effects produced by N+ ion implantation promoted the synthesis of the bioflocculant and increased the flocculating activity.  
        关键词：N+ ion implantation;Bioflocculant;Mutation breeding;Mutagenic effects   
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        发布时间：2021-03-12
      • LI Shuzhen1,2 JIANG Zhongying2 HUANG Yanjun2 HSIA Yuanfu2 1
        Issue 3, (2008)
        摘要：The rare-earth-transition-metal ternary alloy of TbMn6Sn6 was fabricated by conventional arc-melting method. The alloy was examined by X-ray diffraction and the refinement showed its HfFe6Ge6-type crystal structure. The magnetic structures were investigated by combining the 119Sn and 57Fe Mssbauer spectra at different tempera-tures from 20 K to 390 K, and a 90o spin transition behavior was observed at about 310 K.  
          
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        发布时间：2021-03-12
      • SU Qiong WANG Lan CHENG Jianping
        Issue 3, (2008)
        摘要：In this paper, the methods used for processing activity data of radionuclides of short life are presented. A concept of harmonizing efficiency method was employed to improve veracity of efficiency scale in energy range of interest, using the products between efficiencies and activity, i. e. ε (E γ i)×A, of the source being measured, and more satisfying intercomparison result was obtained.  
        关键词：Intercomparison;Yb-169;Harmonizing efficiency method;Methods of processing data   
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        发布时间：2021-03-12
      • LIU Ning XU Gang WU Minghong JIAO Zheng SHI Wenyan OUYANG Shuai TIAN Ling
        Issue 3, (2008)
        摘要：E-beam degradation of dibutyl phthalate (DBP) in oxidation system (acetonitrile/water), reduction system (methanol/water, t-BuOH/water), and pure water systems was investigated. DBP concentration in the four solutions was determined by HPLC, and the degradation products were analyzed by GC/MS. The results showed that the DBP degradation followed pseudo-first-order kinetics. DBP in a concentration of 7.8mg/L, in all solutions but the t-BuOH/water, could be degraded in a rate of over 85% by 0.5 kGy E-beam irradiation The degradation products included diethyl phthalate, bis(2-methylpropyl)ester, and 1,2-Benzenedicarboxylc acid in the three solutions. Finally, mechanism of the DBP degradation was discussed.  
        关键词：Dibutyl phthalate (DBP);E-beam irradiation degradation;Reaction kinetics;Degradation product   
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        发布时间：2021-03-12
      • XIA Jiaoyun1 WANG Yongxian2 YU Junfeng2 YIN Duanzhi2 1
        Issue 3, (2008)
        摘要：It is a novel method for fac-[188Re(CO)3(H2O)3]+ to radiolabel albumin human serum (IgG) indirectly by the pyridyl-containing bis(2-pyridylmethyl)-amino)-acetic acid (L2H). The results show that radiolabeling efficiency of IgG with 188Re(CO)3-L2H-TFP active ester can be higher than 82% under optimized condition. We studied also the labeling stability over 48 h at 37℃ in 0.9% NaCl or bovine serum albumin with both the labeled products. And it shows that the indirect labeling product (90%) has higher radiochemical purity than the direct labeling product (60%). In summary, the symmetric pyridyl-containing tridentate ligand H2L is a potent bifunctional chelator for the future biomolecules labeling of fac-[188Re(CO)3(H2O)3]+.  
        关键词：Rhenium-188;Tricarbonyl complexes;Bifunctional chelating agents;Protein   
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        发布时间：2021-03-12
      • TAN Cheng1 YU Huixin1,2 LIN Xiufeng1 ZHANG Li1 CHEN Bo1 SONG Cuicui2 CAO Guoxian1 1
        Issue 3, (2008)
        摘要：The work was to investigate radioiodinated tetrahydropalmatine and its biodistribution in mice. Tetrahy-dropalmatine was labeled with 131I using the chloramine-T method and the labeled compound were characterized by polyamide TLC. The animals were sacrificed at different times after radiopharmaceutical i.v. administration. The interested tissues samples were collected, and percent injected dose per gram (%ID·g-1) was calculated for each sample. The labeling yield of 131I-tetrahydropalmatine was 76% and its RCPs were 97.3%, 95.4%, and 96.8% after 1, 7 and 20 days, respectively. Biodistribution in mice demonstrated that 131I-tetrahydropalmatine was extensive, and it was me-tabolized mainly in liver and kidney, which contained of 14.35% and 6.55% ID·g-1at 5 min, respectively, with 3.26% and 1.20% ID·g-1at 4h, respectively. Comparatively high 131I-tetrahydropalmatine was found in intestine and fat, but clearance was slow, 3.91%and 3.05% at 5 min and decreased to 0.79% and 0.37% at 4 h. The results also showed that 131I-tetrahydropalmatine could well penetrate the blood-brain barrier to attain a maximal level in brain tissue within 5～10 min, but it mostly was cleaned out after 2 h. There was no significant difference in brain regions despite of highest biodistribution in parietal lobe. In conclusion, 131I-tetrahydropalmatine was stable and it was metabolized mainly in liver and kidney, but there was no significant difference in brain regions.  
        关键词：Tetrahydropalmatine;Radioiodine-labeling;Biodistribution   
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        发布时间：2021-03-12
      • LIU Shubin ZHENG Wei LIU Xuzong AN Qi
        Issue 3, (2008)
        摘要：The TOF (Time-of-fight) trigger system of BES-Ⅲ (Beijing Spectrometer Ⅲ) is faced with the demand of transferring massive high speed data:receiving 368 fast hit signal from the Front-End-Electronics synchronous with the 41.7 MHz clock, sending the processed 4 bits hit number information and 3 bits back-to-back information to the Global-Trigger-Logic with real time, sending processed 136 bits position information to the Track-Match-Logic with real time, and it is desired to provide all the data packet to the DAQ system every 16 valid events, for off-line analysis. During the design, we employed different technical means, such as serialize/de-serialization, fiber, LVDS, VME bus, to achieve the different data transferring requirement. This paper describes the methods we applied in the design.  
        关键词：Trigger;Serialize/de-serialize;Fiber;LVDS;VME;CBLT   
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        发布时间：2021-03-12
      • QIAN Yi1,2 SU Hong1 XU Si jiu1,2 LI Xiaogang1 1
        Issue 3, (2008)
        摘要：A testing system circuit we designed for front-end ASIC of Silicon strip detector is reported in this paper. This ASIC chip can also be used as the front-end electronics for silicon micro-strip, Si(Li) and CsI detectors. The circuit configuration of the test system, circuit design and testing results are described in details. Also, the architecture of the ASIC is introduced briefly.  
        关键词：Silicon strip detector;Front-end ASIC;Test system;Circuit design   
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        发布时间：2021-03-12
      • HE Zhiyi XU Jieping CUI Jian
        Issue 3, (2008)
        摘要：The moveable helium liquefier in the Key Laboratory of Superconducting Cavity Technology of SINAP has stopped operation for years. As the original control system has become obsolete, it is necessary to make some repairs and improvements. The upgraded control system employs a distributed control strategy and a mature PLC technology. The test results show that the new control system can meet the operation requirements of the liquefier well.  
        关键词：Liquid helium;Helium liquefier;Cryogenic control system   
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        发布时间：2021-03-12
      • YAN Shuhua1,2 LI Bin1 1
        Issue 3, (2008)
        摘要：In this paper, we present a coating AFM tip method to facilitate the dip-pen nanolithography (DPN) processes. The small amount of ink can be limited to the apex of atomic force microscope (AFM) tip by adjusting AFM operation parameters. With this automatic AFM-engage system overloading ink, usually disturbing imaging and manipulating, can be avoided. Thereby, a uniform nanoarray of CuCl2 is constructed on a DNA molecule. The unique technique may provide a novel approach to precisely modify biological molecule at the nano-meter scale.  
        关键词：Dip-pen nanolithography (DPN);DNA;Nanoarray;Tip coating   
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        发布时间：2021-03-12
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