最新刊期
      卷 0 ， 期 0 ， 2020
      • LIU Nianqing1 LIU Pingsheng1 HUANG Yuying1 HE Wei1 CHEN Defu2 ZHAO Jinyuan2 1
        Issue 5, (2003)
        摘要：An analytical method for the relative concentration of trace elements in plasma protein by gel chromatog-raphy combined with SRXRF (Synchrotron Radiation X-ray Fluorescence) was developed. The relative concentration of trace elements was obtained using the normalized Compton scattering intensity of protein in X-ray spectra as a function of protein mass. The male Kunming mice were treated with and without cisplatin. The relative change of elements (Pt, S, Ca, Fe, Cu, Zn, Se, Br and Sr) contents in the fraction of the plasma proteins (>22kD) of the mice were obtained. The determination prove that the element Pt in plasma is bound with macro-molecular protein, and that Cu and S are increased while Zn is decrease in the fraction of the protein in mice treated with cisplatin.  
        关键词：SRXRF;Trace elements;Gel chromatography;Cisplatin;Plasma protein   
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        发布时间：2021-03-12
      • ZHANG Jidong CAO Zan REN Fanglin ZHOU Qiaogen ZHANG Lihua LI Yu ZHAO Yubin YAN Heping
        Issue 5, (2003)
        摘要：A long coil magnetic measurement system has been built at SSRC to measure the storage ring dipole magnet prototypes of SSRF. The system consists of a 2.2 m long coil and a control system. The basic design concept is to build a reliable, precise and automatic measurement system for integral magnetic field measurement. A multi-function LabVIEW application program was developed on a personal computer main control unit, with Microsoft Windows 98/2000. Several personal computer slot interface cards communicate with, and control the various devices. The control system is designed to be versatile, modular, expandable, maintainable, quick and easily reconfigurable in both hardware and software. The system is accurate enough to characterize the magnetic field quality of the storage ring dipole magnet prototypes.  
        关键词：Dipole magnets;Integral field;Moving long coil   
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        发布时间：2021-03-12
      • XU Hongliang WANG Lin LIU Jinying SUN Baogen HE Duohui
        Issue 5, (2003)
        摘要：The phase II upgrading project of Hefei 800MeV electron storage ring is being carried out, and its new RF cavity will be finished. In high current operation mode the narrow band coupling impedance of RF cavity can cause different beam bunches to interact, so both longitudinal and transverse coupled modes will be excited. To estimate the effect of the RF cavity coupling impedance on stored bunch intensity fully, the long-range wakefield and the narrow band coupling impedance of RF cavity were calculated with MAFIA program. And the calculation results showed that there are some high order modes in the new RF cavity , which need to be damped.  
        关键词：Wakefield;Narrow band coupling impedance;RF cavity   
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        发布时间：2021-03-12
      • ZHENG Sixiao1 LUO Shunzhong2 LIAO Xiaodong1 LONG Xinggui2 PENG Shuming2 WANG Peilu1 LIU Zhongyang1 LIU Ning1 1
        Issue 5, (2003)
        摘要：Production of Ca+ and He+ ions by Freeman source under the auxiliary of inert gas and the microstructure analysis of both implanted titanium foil and nano- Ti film were described. The XPX analysis for Ti film specimen implanted by Ca+ ion indicated that Ca content reached to 33 % at the implanted dose of 1×1018/cm2, and the titanium surface appeared mainly in the forms of CaTiO3, CaO and TiO2. It is clear that the implanted calcium linked up with titanium monomeric unit in the chemical conjugation. The XRD spectrum for titanium specimen implanted by He+ splits up obviously, and became more acute at the range of 15—40? The crystal sizes of the nano-film specimen on the crystal face of (100) and (101) calculated by Sherrer mode were 19.3nm and 20.2nm after implantation, still remaining nano-crystalline size. The intragranular crystal of nano-film surface reached a certain growth, and the growth of surface grain size of nano-titanium film was observed by AFM at m-visual field, but a large amount of substructure was still observed at nm-visual field. Hance based on AFM observation and XRD analysis, an important phenomenon was found that the surface granules of nano-titanium film existed after high dose implantation; and meanwhile they split up into micro-crystals remaining nano-crystalline gain size.  
          
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        发布时间：2021-03-12
      • WU Baoshan1,2 LING Haiqiu1,2 MAO Peihong1,2 JIN Xiang1,2 ZENG Xianxian1,2 LIU Wei3 GE Jufen3 HAO Weili3 1
        Issue 5, (2003)
        摘要：The mutation effects of N+ ion implantation on cultivated tomato, Catchup type and Eatable type were studied. The result showed that the mutation ranges of single-fruit weight and fruit number per plant were increased and their mutation frequencies were high, however the effect of ion implantation on germination rate of seed and quality of fruit was very weak. Using doses of 4×1016 and 6×1016 N+/cm2 , the yield was greatly improved. The optimum mutation dosage was slightly different for seed of 2 tomato lines.  
        关键词：Tomato;Ion implantation;Mutation breeding;Optimum dosage   
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        发布时间：2021-03-12
      • TAN Jun ZHANG Ping
        Issue 5, (2003)
        摘要：The formation of boron nitride thin films on silicon wafer by ion beam assisted deposition was studied. The experimental study on energy and current of the assisted ion beam and on the percentage of nitrogen in the bombarding gas was carried out. The thin films were analyzed by infrared spectroscopy and X-ray photoelectron spectroscopy. The results show that the c-BN percentage in the films increases with the percentage of nitrogen in the bombarding gas and the c-BN percentage increases when ion beam energy is appropriate, and that ion beam current in the experiment has only little influence on the synthesis of the c-BN thin films.  
        关键词：c-BN thin films;Ion beam assisted deposition;XPS;FTIR   
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        发布时间：2021-03-12
      • LIN Xiangtong
        Issue 5, (2003)
        摘要：This paper describes the current status and prospect of positron emission tomography(PET) in mainland of China. There are 22 PET centers (including those being set up) and 4 PET scanners till March of 2003 . FDG is provided by both 2 sets IBA 30 MeV cyclotrons and 17 house cyclotrons in PET centers. The following key aspects on the development of PET were discussed : PET examination cost has not been covered by the national health care system at present; numbers of PET should be increased limitedly, and its growth-up should keep balance with GDP(economic level); it is necessary to have cooperation between basic sciences (engineering, chemistry, computer science) and clinical medicine (radiology, nuclear medicine, radiotherapy, oncology); we should pay more attention to PET staff training; it is time to found the PET community as a subordinate unit of Chinese Nuclear Society or Chinese Society of Nuclear Medicine, China Medical Association.  
        关键词：Positron emission tomography(PET);Current status;Prospect   
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        发布时间：2021-03-12
      • HUANG Gang MA Yubo LIU Yiwen XIANG Zuolin LU Ping CHEN Meijuan
        Issue 5, (2003)
        摘要：To investigate the therapeutic effect of the 32P contact and laser treatment , 172 cases of condyloma acu-minatum were studied. 100 cases were treated by laser, whereas 72 cases by radionuclide 32P. The clinic cure rate , effective rate, relapse rate and adverse reaction in laser group was 43%, 100%, 57% and 16% , respectively, whereas in 32P group were 87.5% , 100% , 4.2% and 9.7% , respectively. The 32P contact therapy is a simple, noninvasive, ef-fective treatment of condyloma acuminatum with low relapse rate and few side reaction. Therefore, it had good clini-cal value.  
        关键词：P contact therapy;Laser;Condyloma acuminatum   
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        发布时间：2021-03-12
      • YAN Weili SUN Dayu LIN Xiangtong JIANG Yibin SUN Xu LU Hongzhou LIU Xingdang
        Issue 5, (2003)
        摘要：The purpose of this study is to evaluate the feasibility and validity of the breath test with L-[1-13C]phenylalanine orally administrated in assessing liver function quantitatively. L-[1-13C]phenylalanine breath tests were performed in 10 patients with compensated liver cirrhosis, 10 patients with decompensated liver cirrhosis and 10 normal subjects. Breath samples were taken before oral administration and at different time intervals within 360 minutes after administration of L-[1-13C]phenylalanine (100mg / case) and the enrichment of breath 13CO2 was measured by an isotope ratio mass spectrometer. The percentage of 13C excretion rate at 30 minute (13CO2ER30) and the percentage of 13C cumulative excretion within 75 minutes (13Ccum75) were studied among the above groups and were compared to clinical liver function tests. Result showed that 13CO2ER30 were 7.4% 13C dose/h ?.0% 13C dose/h and 3.5% 13C dose/h ?.1% 13C dose/h in patients with compensated liver cirrhosis and patients with decompensated liver cirrhosis, both were significantly lower than that of normal subjects (12.1% 13C dose/h 2.1% 13C dose/h, P<0.001, respectively). 13Ccum75 were 7.0% 13C dose ?.1% 13C dose and 3.8 13C dose ?.0% 13C dose in patients with compensated liver cirrhosis and patients with decompensated liver cirrhosis, and both were also significantly lower than that of normal subjects (10.6% 13C dose ?.6% 13C dose, P<0.001, respectively). These two parameters signifi-cantly correlated with some clinical liver function tests (P<0.05). The present results seem to indicate that oral L-[1-13C]phenylalanine breath test is a simple, sensitive, specific and quantitative test for the measurement of instant liver function, whereas 13CO2ER30 and 13Ccum75 are two useful parameters for evaluation.  
        关键词：L-[1-13C]phenylalanine;Breath test;Liver function;Liver cirrhosis   
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        发布时间：2021-03-12
      • ZHU Cuiying1 SHEN Jiangfan2 HUANG Gang1 YUAN Jimin1 1
        Issue 5, (2003)
        摘要：cases of cholecystic cancer and 205 cases of benign gall bladder diseases measured by CA 242 and CA19-9 immunoassay were reported. Sensitivity of CA 242 and CA19-9 was 84.2% and 94.7%, specificity was 94.6% and 72.7% , and concordance rate was 93.8 % and 74.6% , respectively. Therefore, specificity and concor-dance rate of CA 242 immunoassay was better than CA19-9. It has also been specially investigated the influence of hyperbilirubinemia on results of CA 242 and CA19-9 measurements. By measurements of the serum in patients of chronic liver diseases with jaundice, and also the combined measurement of both serum and bile in patients with gall bladder diseases, it was demonstrated that hyperbilirubinemia greatly affects the results of CA19-9 and therefore plays a main role for its false positivity, but has less effect on CA 242 determination. Thereby, when judging its clinical results, we must pay special attention to hyperbilirubinemia.  
        关键词：CA242 immunoassay;CA19-9 immunoassay;Tumor markers;Cholecyst cancer;Gall bladder diease;Hyperbilirubinemia   
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        发布时间：2021-03-12
      • WU Chunying1,2 LIN Xiangtong1 LU Chunxiong2 ZHANG Zhengwei1 LIU Ping1 XUE Fangping1 1
        Issue 5, (2003)
        摘要：The synthesis and fluoro-radiolabelling of serotonin(5-HT1A) receptor imaging agent 4-18F-fluoro-N-[2-[1-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pridinyl-benzamide,18F-MPPF) was reported . The chemical structure of the nitro- labellng precusor MPPNO2 and all its intermediates were verified by IR, elementary analysis, 1HNMR and MS. Nucleophilic substitution of fluororeplacement reaction was proceeded by oil-bath heating or microwave heating methed. Radiochemical yield by microwave heating was higher than oil-bath heating,whereas synthetic time of the former was much more shorter than the latter. Final radiochemical purity was above 95% deter-mined by TLC . Thereby it can be used preclinically.  
        关键词：Serotonin (5-HT1A) receptor;18F labeling;18F-MPPF;Synthesis.   
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        发布时间：2021-03-12
      • WANG Guohui LIU Changzheng LIANG Changsheng
        Issue 5, (2003)
        摘要：The feasibility of radioimmunotherapy for NPC with 188Re-BAC5, a kind of monoclonal antibody to NPC, was investigated. The 188Re-BAC5 was prepared by direct labeling method and its biological activity was determined. The MTT method was used to determine the inhibition effect of the 188Re-BAC5 on CNE-2 cell line culture, and the destruction effect on CNE-2 multicellular spheroids model was also observed. The control group were 188Re-BSA and 188ReO4-. The biological activity of BAC5 was 1:780000 after purification. The labeling yield of 188Re-BAC5 was above 80%. The immuno-activity of 188Re-BAC5 was 61%±15%. The results of MTT showed that the inhibition ef-fect of 188Re-BAC5 group was much stronger than the control group (P<0.05). In the experiment of tumor multi-cellular spheroids, 188Re-BAC5 had a obvious destruction effect on spheroids, and there was a significant dif-ference between 188Re-BAC5 and the control group. In conclusion, 188Re-BAC5 may serve a possible way in the treat-ment of NPC in the near future.  
        关键词：Nasopharyngeal carcinoma;Antibody;Monoclonal;188Re;Radioimmunotherapy   
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        发布时间：2021-03-12
      • ZOU Baomin DUAN Xiaoyi CHEN Wei HU Guoying
        Issue 5, (2003)
        摘要：To study apoptosis of PC-3 , ER-75-30 and A549 cells induced by radionuclide 153Sm and the expression of bcl-2, bax in apoptosis cells, MTT assay was used to detect the anti-tumor effect, light microscope, transmission electron microscope, flow cytometer were used to detect apoptosis, while image analysis was used to detect the ex-pression of bcl-2 and bax. 153Sm showed anti-tumor effect and could induce tumor cell apoptosis. Both bcl-2 and bax played an important role in apoptosis. Different kind of cells had different sensitivity to 153Sm.  
        关键词：Sm;Apoptosis;Tumor cell;bcl-2;bax   
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        发布时间：2021-03-12
      • HUANG Shaohui 1 DIAO Yao2 GONG Xiangqin3 ZHAO Xun2 YU Chengguo2 1
        Issue 5, (2003)
        摘要：This study demonstrated an effective technique for construction of neovascularized cutaneous cartilage flaps. The central vessels of the pinna and a piece of cantilage were dissected out and placed in a subcutaneous flap pocket of a random-pattern, distally based flap. The neovascularition progress began in 1 week. At 3rd to 4th week, the outgrowth achieved the highest level, and new vessels anastomose in the flaps. In the meantime, new cartilage cells formed.  
        关键词：Prefabricated cutaneous cartilage flap;Autoradiography;Blood vessels   
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        发布时间：2021-03-12
      • LI Yuguo1 HUANG Xuan1 ZHANG Xiaodong1 LIU Ruili1 ZHANG Yongping1 LI Wenxin1,2 1
        Issue 5, (2003)
        摘要：Biodistribution studies of 67Ga-C60(OH)x have been conducted using KM mice. The results showed high localization of the 67Ga-C60(OH)x in the liver, spleen, bone and marrow but with slow clearance. It was also demon-strated that 67Ga-C60(OH)x was unable to cross the blood-brain barrier. The concentration of C60(OH)x affected the biodistribution. These data suggest that C60(OH)x may be used as a carrier of drug delivery system for lymphatic tar-geting due to its behavior as a micro-particle substance.  
        关键词：Fullerol;67Ga-C60(OH)x;Biodistribution   
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        发布时间：2021-03-12
      • HANG Jianzhong1 CAO Weiguo1,2 BAO Borong1,2 HUANG Wei1 CHEN Jie1 1
        Issue 5, (2003)
        摘要：The extraction of U(VI) with HCBMPPT[4-(2chloro)benzoyl-2,4-dihydro-5-methyl- 2-phenyl-3H- pyrazol-3-thione] from nitric acid solution in toluene was studied. The distribution ratio of U(VI) increases with the increasing pH of the aqueous phase. Meanwhile when the concentration of HCBMPPT increases, the distribution ratio of U(VI) increases rapidly. The chemical composition of extracted complex and the mechanism of the extraction reac-tion were discussed.  
          
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        发布时间：2021-03-12
      • CAO Weiguo1,2 HANG Jianzhong2 BAO Borong1,2 HUANG Wei2 CHEN Jie2 1
        Issue 5, (2003)
        摘要：A novel extractant, 4-(4-methoxybenzoyl)-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-thione (HMBMPPT) was synthesized. Its composition and structure were confirmed by elemental analysis, mass spectrome-try, IR, 1H NMR and X-ray crystal analysis. The extraction of U(VI) with HMBMPPT in chloroform from nitric acid solution was studied including influences of diluents, the salting-out agent concentration, acidity in aqueous phase and extractant concentration in organic phase as well as temperature on the distribution ratio. The chemical composi-tion of extraction complex and the extraction mechanism were also discussed.  
        关键词：Extractant;Synthesis;Solvent extraction;Uranium(VI)   
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        发布时间：2021-03-12
      • LAI Yongfang GUO Yong
        Issue 5, (2003)
        摘要：The recent development of micro pattern structure gas detectors has been introduced. Meanwhile the po-tential biomedical application of micro pattern structure gas detectors and the simulation for designing gas detectors have also been discussed.  
        关键词：Micro pattern structure gas detector;Spatial resolution;MWPC   
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        发布时间：2021-03-12
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