Biodistribution of 67Ga-C60（OH）x in mice

LI Yuguo1  HUANG Xuan1   ZHANG Xiaodong1  LIU Ruili1  ZHANG Yongping1  LI Wenxin1; 2 1

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Biodistribution of ⁶⁷Ga-C₆₀（OH）_x in mice

更新时间：2021-03-12

- Biodistribution of ⁶⁷Ga-C₆₀（OH）_x in mice
- NUCLEAR TECHNIQUES Issue 5, (2003)
- 作者机构：
  
  1. 中国科学院上海原子核研究所纳米生物医药研究室
  2. 中国科学院上海原子核研究所纳米生物医药研究室,上海,201800
  3. 中国科学院核分析与核技术开放实验室上海,201800
- 作者简介：
- 基金信息：
  
  国家自然科学基金(No.19975066);中国科学院知识创新重大项目的资助
- DOI：
  CLC： R817
- Published：01 May 2003
- 稿件说明：
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[1]李宇国,黄旋,张晓东,刘瑞丽,张勇平,李文新.~(67)Ga标记C_(60)衍生物C_(60)(OH)_x的生物分布研究[J].核技术,2003(05):393-396.

LI Yuguo1 HUANG Xuan1 ZHANG Xiaodong1 LIU Ruili1 ZHANG Yongping1 LI Wenxin1, 2 1. Biodistribution of ⁶⁷Ga-C₆₀（OH）_x in mice[J]. Nuclear techniques, 2003, (5): 393-396.
[1]李宇国,黄旋,张晓东,刘瑞丽,张勇平,李文新.~(67)Ga标记C_(60)衍生物C_(60)(OH)_x的生物分布研究[J].核技术,2003(05):393-396. DOI：

LI Yuguo1 HUANG Xuan1 ZHANG Xiaodong1 LIU Ruili1 ZHANG Yongping1 LI Wenxin1, 2 1. Biodistribution of ⁶⁷Ga-C₆₀（OH）_x in mice[J]. Nuclear techniques, 2003, (5): 393-396. DOI：

摘要

运用放射性核素67Ga标记技术研究了富勒烯衍生物C60（OH）x在小鼠体内的分布和代谢。研究结果表明

标记物很快被体内各脏器和组织摄取

主要分布在骨髓、骨、肝脏和脾中;肌肉和皮毛较少

不能通过血脑屏障

从血液及其他脏器中清除较慢

未发现急性毒性。结果提示该衍生物具有微粒状特性

有望用作淋巴显像剂或恶性淋巴肿瘤导向治疗的药物载体。

Abstract

Biodistribution studies of 67Ga-C60(OH)x have been conducted using KM mice. The results showed high localization of the 67Ga-C60(OH)x in the liver

spleen

bone and marrow but with slow clearance. It was also demon-strated that 67Ga-C60(OH)x was unable to cross the blood-brain barrier. The concentration of C60(OH)x affected the biodistribution. These data suggest that C60(OH)x may be used as a carrier of drug delivery system for lymphatic tar-geting due to its behavior as a micro-particle substance.

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