最新刊期
卷 0 ， 期 0 ， 2020
- 摘要：A new method for evaluating portal systemic circulation was presented. Following transrectal administration of 99mTc - MIBI it was feasible to detect the presence of portasy-atemic shunting in both animal and patient studies. The heart -liver ratio （H/L ratio） and the portosystemic shunt index （SI） in normal controls were 0. 21±0.08 and 0. 17 ± 0. 06. Whereas in patients of liver cirrhosis with portal hypertension were 1. 12 ± 0. 18, and 0. 54 ± 0. 07 respectively. And showed a significant difference （p<0. 01） between normal and cirrhosis group. A good correlation between the H/L, SI and the portal pressure measurement during operation （r = 0. 93） was also found. Thereby it seems that portasystemic shunting can be quantified with this radionuclide noninvasive method .
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发布时间：2021-04-09 - 摘要：This paper reported the postoperative effectiveness of 39 patients with cardiac valvular replacement. Using radionuclide angiocardiography, the cardiac-pulmonary blood flow . left and right ventricular functions were compared between 39 cardiac patients and 21 normal cases. Above parameters decreased in various magnitude in patient group. After valvular replacement , it was found that the cardiac - pulmonary blood flow has improved in the early stage （within 180 days） while the ventricular function would gradually improved nearly half a year after operation. It was also demonstrated that significantly decreased ejection fraction before operation usually correlated with worse therapeutic effect. Therefore, it was suggested that the valvular replacement should be taken as early as possible in cases of somewhat lowered EF value in order to get better result.
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发布时间：2021-04-09 - 摘要：Radioligand binding assay of receptors with 1251 - iodopindolol revealed that Zhimu can siginificantly inhibit the increase of mouse heart β - adrenoceptors induced by T3. The kinetic parameters were calculated from the data of heart β- adrenoceptor binding sites determined at various periods after irreversible blocking of the preexisting β- adrenoceptors. Zhimu can decrease the production rate and degradation rate constant of hyperthyroid mice by 48 % and 35% respectively. These results indicate that Zhimu can decrease the production rate more potently than the degradation rate of heart β - adrenoceptors in hyperthyroid mice, and hence can make the number,of receptor binding sites approach normal.
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发布时间：2021-04-09 - 摘要：This paper presents the method of labelling DTPA - Ab （antiferretin antibody of human hepatocellular carcinoma ）conjugate with 90Y as well as the analytical method of the labelled compounds. The labelling percentage of the DTPA - Ab conjugate separated by microcen-trifuged column gel filtration using Sephadex G -75 is as high as 92% . After further purification, the radiochemical purity can be higher than 99%. The experimental results also show that the dilution factor of DTPA - Ab conjugate and 90Y as well as the presence of impurity metal ions have great influence on the 90Y labelling of DTPA - Ab conjugate.
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发布时间：2021-04-09 - 摘要：Lipiodol was labelled with 131I using an iodine exchange reaction with acetone as solvent. The labelling rate was 95%. No dehalogenation was detected within 15 days at room temperature or after sterilization. Animal experiments showed that after hepatic arterial injection 131I -lipiodol was selectively accumulated in the embolized local area. No increased activity was observed in the thyroid, lung or other areas. The effective half - life in liver was 4. 92±0. 66 days. The blood radioactivity per ml was 0. 09±0. 04% of the injected dose . The results suggest that the 131I - lipiodol is very stable and suitable for clinical application.
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发布时间：2021-04-09 - 摘要：A simple , sensitive, accurate and reproducible protein binding assay of cAMP in platelet was established. The level of cAMP in platelet were determined in 30 normal subjects and in 26 patients with idiopathic thrombocytopenic purpura（ITP）. The results showed that the level of cAMP in ITP was significantly higher than those of normal group , and the concentration of cAMP in platelet was not correlated with plasma concentration. Finally, the methodology of cAMP in platelet and the causes of abnormality of cAMP in platelet during ITP were also- discussed.
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发布时间：2021-04-09 - 摘要：99mTc - MIBI myocardial tomography imaging was obtained from 119 cases with Sopha Medical SPECT system. 38 cases of coronary heart diseases, 33 cases of coronary heart diseases combined with hypertension and 48 cases of myocardial infarction were diagnosed according to clinical symptoms and signs, ECG,exercise ECG（treadmill test）and other laboratory studies. The results showed that positive rate of myocardial tomogarphy imaging for detecting coronary heart disease was 70. 21% at rest, and the positivity can be further increased by myocardial tomography imaging with exercise test. On the contrary the positivity of exercise ECG was only 63.8%. It was concluded that radionuclide myocardial tomography imaging was noninvasive and more sensitive and specific than the exercise ECG in detecting coronary heart disease.
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发布时间：2021-04-09 - 摘要：A diabetic model with alloxan in Will’s rat has been established and the function of α,β, D cells of its pancreas were studied. The plasma level of glucagon, somatostatin and insulin in portal and caval vein were measured by RIA. The results showed that the glucagon and somatostatin were significantly increased , while the insulin was decreased. The results demonstrated that the changes of somatostatin was somewhat reiated also to diabetes and the experimental studies have supported this concept that the increasing of somatostatin level will inhibit the increasing of glucagon and thereby the hyperglycemia would be alleviated.
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发布时间：2021-04-09 - 摘要：The synthesis of 211 At labelled 3H11 monoclonal antibody was performed by an activation reaction of carboxy via paraastato - benzoic acid intermediate. Its specific radioactivity was 18. 5-61. 1kBq/μg . Its immunoactivity was measured by ELISA method. In vitro binding and cytotoxic experiments showed when the 211At - 3H11McAb concentration is raised, the cytotoxic effect increased and have obvious selectivity. The cytotoxic effect of 211At - 3H11 McAb to target cell M85 was higher than that of 211At - IgG and Na211At . If the M85 cells were cultured with 3H11 McAb or 3G9McAb for 1 h at first, the cytotoxic effect of 211At -3H11McAb was inhibited. The specific radioactivity of 211At - 3H11McAb and cytotoxic effect are also discussed.
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发布时间：2021-04-09 - 摘要：Epimedium Brevicornum Maxim （EBM）can increase β- receptor binding sites in lungs ofrats and raise the cAMP content and cAMP/cGMP ratio in plasma and lung of rats. ThecGMP and E2 in plasma and lung of rats were decreased and cAMP/cGMP ratio was in-. creased by Radix Rehmannial Liquid（RRL）. Both drugs, EBM and RRL, can raise cortisolconcentration in plasma of rats.
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发布时间：2021-04-09 - 摘要：The paper described the study of serum - hormone levels by radioimmunoassay in 525 patients with male sexual insufficiency. The results showed that testosterone （T） level in 50 normal cases were 501. 0±108. 0ng/dl, but serum FSH, LH and PRL were 13. 6±8. 2mIU/ ml, 7.8 ± 5. 5mIU/ml, 15.97 ±5-43ng/ml respectively. 15 cases of genetype with klinefelter’s syndrome are all 47, XXY . No significant difference were noted in the serum T levels between klinefelter’s syndrome and normal controls, but the serum FSH was significantly increased （58. 78±22. 07mIU/ml）. If the level of T falls and FSH and LH rise the sterility mostly results from testical diseases. If T, FSH and LH are all normal, in most cases the sterility results from obstructed aspermia. If the PRL rises and T, FSH and LH are all in lower values it would be possibly hypogonadotrophinmia. If T is low, FSH and LH rises, the under development of testes should be considered.
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发布时间：2021-04-09 - 摘要：Twenty nine patients were studied by obtaining six plasma samples for each clearance curve at 10 to 90 min after injection as a reference standard. ERPF has been calculated from a two-compartment model analysis （Sapirtein Method）. The standard error of estimate （Sy.x） by single 49 min sample was 65.6ml/min. By using two samples （at 10 and 90 min）, Sy.x-could be reduced to 20. 7ml/min.
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发布时间：2021-04-09
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