Labelling of DTPA - coupled antiferretin antibody of human hepatocellular carcinoma with <sup>9</sup>0Y

Zhu Jianhua Zhong Gaoren Zhao Ke Dai Wei

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Labelling of DTPA - coupled antiferretin antibody of human hepatocellular carcinoma with ⁹0Y

更新时间：2021-04-09

- Labelling of DTPA - coupled antiferretin antibody of human hepatocellular carcinoma with ⁹0Y
- NUCLEAR TECHNIQUES Issue 11, (1992)
- 作者机构：
  
  1. 上海医科大学
  2. 上海医科大学,上海,200032
  3. 实习生,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 November 1992
- 稿件说明：
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[1]朱建华,钟高仁,赵可,戴微.~(90)Y标记DTPA—抗人肝癌铁蛋白抗体[J].核技术,1992(11):656-660.

Zhu Jianhua Zhong Gaoren Zhao Ke Dai Wei. Labelling of DTPA - coupled antiferretin antibody of human hepatocellular carcinoma with ⁹0Y[J]. Nuclear techniques, 1992, (11): 656-660.
[1]朱建华,钟高仁,赵可,戴微.~(90)Y标记DTPA—抗人肝癌铁蛋白抗体[J].核技术,1992(11):656-660. DOI：

Zhu Jianhua Zhong Gaoren Zhao Ke Dai Wei. Labelling of DTPA - coupled antiferretin antibody of human hepatocellular carcinoma with ⁹0Y[J]. Nuclear techniques, 1992, (11): 656-660. DOI：

摘要

介绍了

Y标记DTPA-抗人肝癌铁蛋白抗体联结物的标记方法及标记物的分离和分析方法

并对几种标记方法进行了比较

认为用微量离心柱分离DTPA-抗体联结物

而后进行

Y的标记

效果最好

标记率高达92％。标记物经进一步纯化

其放化纯度可达99％以上。抗体经标记后免疫活性无明显损失。实验结果还表明

DTPA-抗体联结物和

Y的稀释效应及标记体系中杂质金属离子的存在均对

Y的标记有极大的影响。

Abstract

This paper presents the method of labelling DTPA - Ab （antiferretin antibody of human hepatocellular carcinoma ）conjugate with 90Y as well as the analytical method of the labelled compounds. The labelling percentage of the DTPA - Ab conjugate separated by microcen-trifuged column gel filtration using Sephadex G -75 is as high as 92% . After further purification

the radiochemical purity can be higher than 99%. The experimental results also show that the dilution factor of DTPA - Ab conjugate and 90Y as well as the presence of impurity metal ions have great influence on the 90Y labelling of DTPA - Ab conjugate.

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Labelling of DTPA - coupled antiferretin antibody of human hepatocellular carcinoma with 90Y

DOI：

摘要

Abstract

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Labelling of DTPA - coupled antiferretin antibody of human hepatocellular carcinoma with ⁹0Y