最新刊期
      卷 0 ， 期 0 ， 2020
      • Issue 5, (1996)
        摘要：Oncomodulin （oncoM）──a mark of tumor was purified from human tumor tissues,and was labelled with high specific radioactivity by conjugating to an 125I-iodinisated acylating agent.The specific activity of 125I-oncoM was 0.20-0.34MBq/μg and its radiochemical purity was 96%. Radioimmunoassay showed that the 125I-oncoM was able to combine with oncoM antibody specifically. The binding rate was 40% at antiserum dilution of 1:4000.Competitive inhibition curve was obtained in the presence of unlabelled oncoM.  
        关键词：Oncomdulin;Conjugation method;Competitive inhibition curve   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：Brain perfusion imaging agent 99mTc-MRP20 was studied majoring on the radiochemistry and preliminary pharmacological experiments.This paper reports the best labelling condition range,biodistribution results in mice, kinetics of rabbit Blood clearance,partition coeffcient at PH 7.0 and 7.4 and imaging studies in monkeys.  
          
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：total gastrectomy（TG）cases with Roux-Y esophagojejunostomy and 12 subtotal gastrectomy（STG） cases with Billroth Ⅱ gastrojejunostomy were examined with 99mTc-PHY semisolid gastrointestinal imaging.The gastric half emptying time（GHET）and mean intestinal transit time（MITT）were analyzed.The GHET of normal subjects（NOR）,STG and TG group were 33.7,19.65 and 8.3 min. respectively.There was significant difference between them （P<0.05）.The MITT of NOR,STG and TG was 197.4,202.58 and 237.22,respectively.The MITT in TG was significantly slower than that of NOR（P<0.01）and STG （P<0.05）.This report provided a new valuable method for detecting gastroinstestinal function disorders.  
        关键词：Radionuclide imaging;99mTc-PHY;Intestinal function;Gastrectomy   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：Human hyaluronic acid（HA） in 191 healthy donors were studied.It was found that serum HA concentration was significantly elevated（2038.39±336.51 μg/L）in fetuses and still at higher level（720.81±385.76μg/L）in neonates. It decreased gradually with aging and maintained a steady state at 45.92±35.92 μg/L 6 months after birth. Patients with neoplasm had increased HA in blood,and an elevated HA value in CSF was noted for patients with malignancy of central nervous system.As fetal tissues contain a large amount of HA,increased HA concentration in patients with neoplastic disease may be regarded as an oncofetal phenomenon.  
        关键词：Human body hyaluronic acid;Fetal phenomenon;Neoplasm;Oncofetal phenomenon   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：The human granulocytes were isolated.Using hybridoma technique,a hybridoma cell line（HSN）producing monoclonal antibody against human granulocyte was obtained. The antibody belonged to IgG1 subclass.It was confirmed by immunohistochemical methods that HSN reacted selectively not only with human granulocytes,but also with their bone marrow precursors.Whereas human lymphocytes and red blood cells remained negative.No cross reaction was observed with peripheral blood cells in other animals.Its affinity constant was 5.7×108 L/mol,and the number of epitopes per granulocyte was 4.7×105.Monoclonal antibody displayed no loss of immunoreactivity after labelled with 99mTc.  
          
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：Serum osteocalcin in 46 patients with osteal disorders was tested using radioimmunoassay （RIA）.In some of cases, their forearm bone mineral density and serum AKP,calcimn and phosphorus were determined,and compared with osteocalcin.As a result,the osteocalcin level was higher than the normal controls in serum of 32 patients with primary osteoporosis（P<0.01）,7 patients with primary hyperparathyroidism（P<0.01）and 2 patients with chronic renal insufficiency（P<0.05）.Therefore serum osteocalcin and bone mineral density deterfornation have some value for the diagnosis of osteoporotic diseases.  
        关键词：Osteocalcin;Bone mineral density;Radioimmunoassay   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：Four different kinds of bone graft were implanted in right or left defective radius of rabbits:perforated decalcified bone matrix（PDBM）,non-perforated decalcified bone matrix（NPDBM）,perforated stirface-decalcified bone（PSDB）and non-perforated surface-decalcified bone（NPSDB）.After implantation, the rabbits were killed at 2,4,8 and 12 weeks respectively,and studied by radionuclide bone imaging,then compared by radiological and histological examinations.The results showed that perforations on bone may enhance the incorporation between graff and host bone and the new bone formation. SDB has the same osteogenesis induction effect as DBM.It was concluded that 99mTc-MDP bone imaging was an effective and first chosen method for the early diagnosis of viability in bone allograft.  
        关键词：Bone allograft;Radionuclide bone imaging   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：new technetium labelled myocardial imaging agent teboroxime is reported. Its quality is identified after labelling.The results indicate that its physical, chemical and biological aspects are in accordance with radiopharmaceutical quality control standard made by our country.The animal experiment shows that there is no difference between the experimental group and the control group after injecting one hundredfold human’s dose in mice.After injection 0.1ml（207.2kBq/per mouse）,the myocardial peak uptake is observed at the second minute,which is 17.75±0.33%（gorgan）-1, the heart clearance is also rapid,at the 15th minute postinjection,the uptake by myocardium is 8.24±4.72%（g organ）-1.The liver is the major excretion organ.The characteristic of pharmacokinetium in rabbits can be a pharmacokinetics basis for a rapid planar myocardial imaging protol of multiple position.  
          
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：For the detection of the viability and function of the autotyansplanted spleenic tissue,57 cases of spleenic autotransplantation were performed the 99mTc-denatured erythyrocyte imaging,among them 43 cases were imaged within 1 month after operation.Results showed that in 35 of the 43 cases,the transplanted spleens were well visualized,whereas 8 not.Another 14 cases imaged within 1 month and 2 years after operation the implanted spleens were clearly visualized and well functioned.In 24 out of above 43 cases reexamined within 2 years,21 originally visualized still showed the functional spleen,2 of the 3 nonvisualized cases demonstrated functional spleens,and 1 still nonvisualized.  
        关键词：Radioisotope imaging;Spleenic autotransplantation;￣（99）mTc-labelled denatured erythyrocyte   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：cases of scrotal blood now and pool imaging,among them 6 testicular torsion,12 testitis or epididythitis,2 undescended testis and 4 normals were studied.A bolus of 99mTcO4-555-740MBq was given and then dynamically imaging,2s per frame,totally 200s acquisited,afterwards the static imaging was taken immediately.For testicular torsion patients,the diseased testicle showed decreased activity, whereas in testitis patients,the testicle showed increased perfusion. Regions of interest（ROI）were drawn in the normal and abnormal testicle and the respective inner side of leg,and then three counting ratio,i.e.normal testicle/leg,abnormal testicle/leg and normal/abnormal testicle calculated.The three ratios in testicular torsion and testitis group were 1.18,0.75,1.61 and 1.68,2.57,0.60 respectively. It was noticed that all these values have some reference for clinical diagnosis of testicular diseases.  
        关键词：Radionuclide;Scrotal imaging;Acute scrotal pain;Testicular tersion;Testitis;Epididymitis   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：Tc-ECD SPECT cerebral blood flow perfusion imaging has been performed in 70 patients of cerebrovascular disease,including cerebral infarct,TIA and vertebral hasal artery insufficiency（VBI）.The results were compared with CT and MRI.The positive rate of SPECT in diagnosis of cerebrovascular diseases was 90%,whereas CT and MRI 88.2% and 90% respectively.Fifty-one of the 55 cerebral infarct patients have decreased cerebral blood flow perfusion,4 had crossed cerebellar diaschsisThe positive rate of SPECT in diagnosing TIA and VBI are both 75%.More abnormal areas were found in SPECT image than CT and MRI.For detection of viability of brain tissue after cerebral ischemia and infarction,it can provide an evidence for clinical therapy,and also a useful tool in diagnosis of TIA and VBI.  
        关键词：SPECT;Cerebral blood flow;Cerebrovascular disease   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：he whole by body imaging were performed in 468 cases of nasopharyngeal carcinoma patients. The results showed that the incidence of bone metastasis was 56.28%. In 130 of 468 patients performed also with skull tomography the incidence of bone metastasis can raise to 66.3%.Finally,the manifestation of bone metastatic lesion in bone imaging, the route of metastasis,the basic method for controlling the bone metastasis, the following up of the disease and the differentiation between benign and malignancy lesion in bone imaging etc.were also discussed.  
        关键词：Nasopharyngeal carcinoma;Whole body bone imaging;SPECT   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：A comparative study has been made among the result of radioinununoimaging with the blood CEA level,the size of the tumor,the CEA content and the distribution in the tumor,the CEA content and the distribution in the resected tumor tissue by immunohistochemical examination in 20 cases of primary colorectal cancer and 4 recurrent cases, were proved by pathologic section. It was shown that the quality of the radiommunoimaging had no relationship with the blood CEA level（P>0.05）,but was significantly correlated with the main diameter of tumor, the CEA content and the positive CEA reaction distribution in the tumor tissue （P<0.05）.  
        关键词：Monoclonal antibody;Colorectal carcinoma;Radiommunoimaging;Immunohistochemical staining   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：The Log/Linear relationship of serum TSH/FT4 was analyzed in 245 patients of hypo-and hyperthyroidism including subclinical cases.The serum TSH level was much lower（i.e.<0.3mU/L）and serum FT4 level was within normal limits in patients with subclinical hyperthyroidism.The serum TSH level elevated over 5mU/L and serum FT4 level was within normal limit in patients with subclinical hypothyroidism.The TSH/FT4 Log/Linear relationship mapping can clearly reflect the area distribution of various functional status of different thyroid diseases.Besides,the characteristic manifestation of the subclinical thyroid diseases demonstrated that any subtle changes in serum FT4 level induced the amplified response in serum TSH level.  
        关键词：Subclinical thyroid disease;TSH/FT4;Log/Linear relationship   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：Experimental radioimmunotherapy investigation of α-emitting radionuclide.211At labelled anti-gastric cancer monoclonal antibody 3H11 and its Fab fragment for nude mice carrying human gastric cancer xenografts was conducted.Three i.p.injections of 14.8 or 22.2 kBq/g mouse were given, once every 5 days.The results showed that the growth of tumor xenografts was inhibited efficiently.The most evident therapy effect was observed at 15 days after treatment,and the tnmor inhibition rates were 65% and 72%,respectively.No radiation injury of important organs was found.  
        关键词：Astatine-211;Monoclonal antibody;Gastric cancer;Xenograft;Radioimmunotherapy;Nude mice   
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        发布时间：2021-04-09
      • Issue 5, (1996)
        摘要：Heart phantom and clinical study of 99mTc-MIBI SPECT with 180°（LAO to RAO）data acquisition was camed out and compared with the full 360°rotation.Data analyses included myocardial volume and area,defect Volume and area.In simple heart phantom study,360°acquisition was more aseroximate to phantom determined true value （P>0.05）.However,when a hesrt phantom was wraped in a chest phantom, 180°data acquisition was more accordant with thee value （P>0.05）.In 34 cases with coronary heart disease, all of the quantitative parameters mentioned above were very accordant between 360,/6°and 180°/6,180°/6°and 180°/3°The defect-to-normal wall-count ratio（D/N） was lower in the 180°scan （0.235±0.043）than in the 360°scan（0.249 ±0.057） （P<0.05）,indicating the lesion site can be better detected by the former method.All of the results suggested that for myocardial SPECT the 180°acquisition method can save acquisition time and is more practical in the clinical appliance than 360°acquisition.  
        关键词：Heart phantom;Radionuclide imaging;Coronary heart disease   
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        发布时间：2021-04-09
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