Serum osteocalcin in 46 patients with osteal disorders was tested using radioimmunoassay （RIA）.In some of cases

their forearm bone mineral density and serum AKP

calcimn and phosphorus were determined

and compared with osteocalcin.As a result

the osteocalcin level was higher than the normal controls in serum of 32 patients with primary osteoporosis（P<0.01）

7 patients with primary hyperparathyroidism（P<0.01）and 2 patients with chronic renal insufficiency（P<0.05）.Therefore serum osteocalcin and bone mineral density deterfornation have some value for the diagnosis of osteoporotic diseases.