Experimental study on￣（211）At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice

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Experimental study on￣（211）At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice

更新时间：2021-04-09

- Experimental study on￣（211）At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice
- NUCLEAR TECHNIQUES Issue 5, (1996)
- 作者机构：
  
  四川大学原子核科学技术研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R446.62
- Published：01 May 1996
- 稿件说明：
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[1]金建南,刘宁,张叔渊,张仕元,罗德元,周懋伦.~（211）At标记单克隆抗体3H11及其Fab片段对裸鼠人胃癌移植瘤导向治疗的实验研究[J].核技术,1996(05):297-300.

Experimental study on￣（211）At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice[J]. Nuclear techniques, 1996, (5).
[1]金建南,刘宁,张叔渊,张仕元,罗德元,周懋伦.~（211）At标记单克隆抗体3H11及其Fab片段对裸鼠人胃癌移植瘤导向治疗的实验研究[J].核技术,1996(05):297-300. DOI：

Experimental study on￣（211）At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice[J]. Nuclear techniques, 1996, (5). DOI：

摘要

用α放射性核素２１１Ａｔ标记的抗胃癌单克隆抗体３Ｈ１１和它的Ｆａｂ片段进行了荷人胃癌裸鼠的实验性治疗研究。经腹腔注射１４．８或２２．２ｋＢｑ／ｇ鼠的标记单抗，每５天一次，连续三次。治疗结果表明，此单抗对肿瘤有较强的抑制作用，治疗１５天后疗效最显著，抑制率分别达６５％和７２％。未发现各重要器官有明显的辐射损伤。

Abstract

Experimental radioimmunotherapy investigation of α-emitting radionuclide.211At labelled anti-gastric cancer monoclonal antibody 3H11 and its Fab fragment for nude mice carrying human gastric cancer xenografts was conducted.Three i.p.injections of 14.8 or 22.2 kBq/g mouse were given

once every 5 days.The results showed that the growth of tumor xenografts was inhibited efficiently.The most evident therapy effect was observed at 15 days after treatment

and the tnmor inhibition rates were 65% and 72%

respectively.No radiation injury of important organs was found.

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