最新刊期
      卷 0 ， 期 0 ， 2020
      • HE Xiaoye1 HUANG Kaixi2 CHEN Senyu2 LIU Zuping1 ZHAO Yinghai3 1
        Issue 5, (2006)
        摘要：In the hydrostatic leveling system (HLS) the working medium is liquid. Because of its merits, water is chosen as the working medium in the HLS. In the HLS system both pressure and temperature have great effects on the surveying results. In this article the influences of pressure and temperature on the HLS are analysed. In order to dispel the influence of pressure on the system, sealing the vessels and connecting the whole system to a common air circuit were adopted as the solution. This circuit was set under ambient atmospheric pressure at a single point of the network. The influence of temperature on HLS includes the temperature gradients existing in the water pipes and thetemperature difference among vessels. After analysis we know that, if we can keep the water level of the pipes as equal as possible when the system is assembled, the influence of the temperature gradient can be eliminated effec- tively. For correcting the effect of temperature variation among vessels, temperature sensors were installed in every vessel to survey the real-time temperatures, and the data were be collected along with the CCD data. And it is through theoretical analysis that we can get the correction formula, by which the errors resulting from the temperature varia- tion can be corrected.  
        关键词：Hydrostatic leveling system;Pressure;Temperature   
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        发布时间：2021-03-12
      • WANG Naxiu ZHU Yi ZHU Weihua FU Yuan XIA Shaojian
        Issue 5, (2006)
        摘要：We reported the simulation result of crystal thermal distortion of the crystal monochromator by ANSYS, and the result was then compared with the experimental one. Both results are coincident within ±15%, proving the re- liability of the method of using approximate boundary conditions in the process of finite element analysis for the synchrotron radiation crystal monochromator.  
        关键词：Synchrotron radiation;Crystal monochromator;Thermal distortion;Finite element analysis   
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        发布时间：2021-03-12
      • LIU Qi ZHU Zhiyong YAO Side SONG Yufeng
        Issue 5, (2006)
        摘要：The conductometric method used for monitoring track etching processes in polymeric materials was in- troduced. Considering the improper application of some assumptions in data analysis, models were proposed and nu- merical calculations were conducted by taking into account of track break-through time distribution, pore shape as well as etchant conductivity inside small pores. The analysis has provided new information related to latent track structure, etchant conductivity inside pores and the influence of track etching rate ratio on the pore shape.  
        关键词：Polymeric materials;Ion track;Chemical etching;Conductance measurements;Numerical analysis   
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        发布时间：2021-03-12
      • TIAN Xiubo YANG Shiqin
        Issue 5, (2006)
        摘要：Plasma immersion ion implantation (PIII) is an effective surface modification tool. During PIII processes, the objects to be treated are immersed in plasmas and then biased to negative potential. Consequently the plasma sheath forms and ion implantation may be performed. The pre-requirement of plasma implantation is that the object is conductive. So it seems difficult to treat the insulating materials. The paper focuses on the possibilities of plasma implantation into insulating materials and presents some examples.  
        关键词：Plasma ion implantation;Insulating materials;Plasma sheath;Surface charging   
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        发布时间：2021-03-12
      • SUN Tianxi LIU Zhiguo WANG Yan DING Xunliang
        Issue 5, (2006)
        摘要：In order to avoid dead time problems in the detector system, the knife-edge made of polymethyl methacrylate is used as a scatterer. By using the backscattered spectrum from the knife-edge, the space distribution of the X-rays with different energies in the beam focused by the polycapillary X-ray lens, and the energy dependence of the focal spot size, divergence and output focal distance of the lens are measured over a broad energy range at the same time. The halo effect is analyzed in detail. Compared with the results from the existing method, the relative er- rors of the results for the focal spot size obtained by using the backscatter method are within 3%. Absolute errors of the measured output focal distance range from –120 to 120μm.  
        关键词：Polycapillary X-ray lens;Performance measurement;Knife-edge made of polymethyl methacrylate;Backscattering   
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        发布时间：2021-03-12
      • WEI Shenglin1,2 WU Lijun2 XIE Chuanxiao2 YU Zengliang2 1
        Issue 5, (2006)
        摘要：There are many glands that can secrete polysaccharide, forming transparent ball-like liquid drops on the head of glands on Liquorice leaves. All glands on function leaves secrete polysaccharide and accumulate on the head of glands. The ball-like polysaccharide drop on the head of glands have remained on the withered and yellow leaves. Some stimulation effects on the number of glands, the quantity of polysaccharide secretion, internal polysaccharide in leaves and total polysaccharide of leaves are shown after 10 keV, total dosage of 4.68×1016/cm2 N+ was implanted into Liquorice seeds. When 15 keV N+ were implanted , the polysaccharide secretion increased by 44.1% as compared with controls (P<0.01); and it increased by 31.8% (P <0.01) after 20 keV ions were used. The secretion showed evi- dently the positive correlation with the number of glands (r=0.4537, P <0.1). These N+ implantation parameters can provide reference for Liquorice breeding with ions beam.  
        关键词：Liquorice;Gland characters;N+ implantation;Liquorice polysaccharide   
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        发布时间：2021-03-12
      • RAN Tiecheng1,2 LIU Ruili1,2 YIN Juanjuan1,2 LI Qingnuan1 ZHU Jianhua3 LI Wenxin1 1
        Issue 5, (2006)
        摘要：The purpose of this article is to study the synthesis and radioiodination of the fullerene derivative con- taining active antitumor groups. The fullerene pyrrolidine benzoyl nitrogen mustard was synthesized by 1,3 di- pole[3+2] cycloaddition reaction with fullerene, N-methylglycine and N,N-bis(2-chloroethyl)-4-aminobenzaldehyde. Its chemical structure was characterized by the spectroscopic data. The synthesized compound, after connected with the stable iodine, was radiolabeled with iodine-125 through isotope exchanging. Dependences of radiolabeling yields on both reaction temperature and exchanging-time were examined. The results showed that the radiolabeling yield of fullerene pyrrolidine benzoyl nitrogen mustard was as high as 94 % after heating for 2 hours at 130℃.  
          
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        发布时间：2021-03-12
      • CHEN Jian1 ZHANG Zhengwei2 GUAN Yihui2 ZHU Jianhua1 1
        Issue 5, (2006)
        摘要：The preparation of a 18F-labeled imaging agent with higher affinity to dopamine D2 receptor is reported. The ligand of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5- [N-(2-[18F]fluoroethyl)-N-methylsulfonyl]amino-2- methoxybenzamide (18F-FSABZM) was synthesized by nitryl reduction, N-dihydroxyethylation, and methylsulfon- ylation. Finally, 18F-FSABZM was prepared by nucleophilic fluorination of the mesylate with K18F/K222(Kryptofix). The chemical structure of the fluoro-labeling precursor SABZM,the labeling product with non-radioactive fluorine and all other intermediates were validated by 1HNMR and MS. Determined by HPLC, the labeling yield was 12%— 15%. After purifying, the resultant 18F-FSABZM, with a radiochemical purity of over 97%, was stable for more than 4 hours at room temperature. The whole process (including synthesis and analysis) took only 80—90 minutes.  
        关键词：Dopamine D2 receptor;18F labeling;18F-FSABZM;Synthesis   
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        发布时间：2021-03-12
      • SHENG Xujing MENG Laping ZHU Jianhua
        Issue 5, (2006)
        摘要：The purpose of the presented work is to synthesize 99Tcm-labeled dopamin D2 receptor imaging agent 2-{1-[(1-Ethoxycarbonyl-2-mercapto-ethylamino)-methyl]}-3-{4-[(1 -ethyl pyrrolidin-2-ylmethyl)-carbamoyl]-3- methoxy-5-bromo-phenylamino}-propylamino)-3-mercapto-propionic acid ethyl ester (99Tcm-m-Br-p-EBZM). The ECD was coupled with the benzamide derivative, N-[(1-ethyl-2-pyrrolidinealkyl)methyl]-4-acetylamino-5-bromium- 2- methyloxygen- benzol formamide, to yield m-Br-p-EBZM. The labeling compound was prepared through two steps of exchange labeling with 99Tcm-glucohetonate, and its stability was observed. Results show that m-Br-p-EBZM was synthesized for the first time, and was successfully labeled with 99Tcm with 98% of radiochemical purity, high stability and good liposolubility. Hence 99Tcm-m-Br-p-EBZM may become a potential dopamine D2 receptor imaging agent.  
        关键词：Dopamine D2 receptor;CNS receptor imaging agent;99Tcm-labeling   
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        发布时间：2021-03-12
      • SU Chenghai1 FA Yihua1 XU Yujie2 FAN Wo2 1
        Issue 5, (2006)
        摘要：To investigate appropriate dose range in low-dose-rate γ irradiation and to establish a useful method for the research of radioactive biological effect produced by low does-rate γ irradiation, we have studied apoptosis of Hela carcinoma cells induced by different low dose rates of γ irradiation in vitro. The cultured cells were exposed to defined radiation doses from a 60Co therapy source. The radiation source delivered a dose rate of 1Gy/min and gave total dose of 1, 2, 5, 10 and 15 Gy respectively. Using Annexin V labeled by fluorescein and PI, followed by flow cytometry and DNA ladder analysis and confocal microscope, apoptotic cells were detected and quantified. The re- sults are as follows: (1) Determination of apoptosis by flow cytometry indicated that percentage of apoptotic cells was increasing with dose and time. When cells were cultured for 168 h after irradiation, the highest percentage of apop- tosis was yielded in all groups. When the cells were irradiated with 1—2 Gy, no significant increase in the number of apoptotic cells could be seen. After a total dose of 5 Gy, however, a significant increase in the ratio of apop- totic/nonapoptotic cells was observed, and apoptosis reached a peak level of (72.57±2.04)% (P <0.001). (2) The typi- cal appearance of Hela cells stained by annexin V-Fluos for detection of apoptosis exhibited a plasma mem-brane-localized fluorescence that is an early sign of apoptosis under laser confocal microscope. PI entered into the cells slowly while in later apoptosis, with special laser which were red in center and green around, however, necrotic cell only emitted red laser. (3)The presence of apoptotic cells were confirmed by the DNA ladder formation assay, with typical formation of apoptotic fragments. DNA laddering reached the greatest after a single radiation dose of 5 Gy. (4) Over the dose interval from 2 to 15 Gy with a dose rate of 1 Gy/min, the survival of the cells decreased from (58.95±0.36)% to (1.67±0.35)% (P <0.001) by clonogenic assay. It was concluded that the low-dose, low-dose-rate γ irradiation delivered by 60Co sources to Hela cells can induce a significant apoptosis rate, and a maximum level of apoptosis as high as (72.57±2.04)% for an irradiation dose of 5Gy can be reached .  
        关键词：Gamma irradiation;Dose rate;Hela cell line;Apoptosis   
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        发布时间：2021-03-12
      • LI Gucai YIN Duanzhi CHENG Dengfeng WANG Mingwei ZHENG Mingqiang WANG Yongxian
        Issue 5, (2006)
        摘要：Dopamine D4 receptor is a G-protein coupled receptor and it is hypothesized to relate with the patho- physiology and pharmacotherapy of schizophrenia while its level in brain regions is much lower. With the help of nu- clear medicine imaging technology and suitable imaging agents, the receptors’ distribution and the level variation can be determined in living bodies. In this article we describe the synthesis of a putative dopamine D4 receptor radioli- gand, 3-(4-[18F]fluorobenzyl)-8-hydroxy-1,2,3,4-tetrahydrochromeno[3,4-c] pyridin–5-one (18F-FHTP) from 4-trimethylammoniumbenzaldehyde triflate through a two-steps one-pot procedure with a total radiochemical yield of 19.7% (decay-corrected). The radiochemical synthesis of 18F-FHTP took about 105 min and its specific activity was greater than 120GBq / μmol.  
          
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        发布时间：2021-03-12
      • XU Changde CHEN Shaoliang YAO Ruimin ZHANG Qingyong SHI Hongcheng
        Issue 5, (2006)
        摘要：The objective of the work is to observe the role of 99Tcm-sestamibi perfusion imaging and coincidence imaging with 18F-FDG for detecting viability of infarct myocardum in miniswine model. Six minipigs with circum- flex branch ligation for the myocardial infarction underwent excising and resting myocardial perfusion imaging with 99Tcm-MIBI by using single photon emission computed tomography (SPECT) and fast and glucose-injection coinci- dence imaging with 18F-FDG. They also underwent the imaging before operation as a normal control group. The re- gion of myocardial infarction of the model was found no uptake of the 99Tcm-MIBI and 18F-FDG. Part myocardium can be imaged in fast state, and after injecting 18F-FDG the images in this region get fainter. It is concluded that the coincidence imaging with 18F-FDG is better to diagnose the viability of infarct myocardium, and fast and glucose stress can display viability of severe ischmia myocardium.  
        关键词：18F-FDG;99Tcm-MIBI;Myocardium viability   
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        发布时间：2021-03-12
      • CHEN Liguang1,2 TANG Anwu1 WANG Shuxia1 HE Shanzhen1 DING Zhenhua2 1
        Issue 5, (2006)
        摘要：The [11C]methyl iodide (11C-CH3I ) is a very important methylated precursor in 11C labeled PET tracer synthesis. In order to get higher and more stable radiosynthesis yield of 11C-CH3I, this research aims at optimizing the key steps over the radiosynthesis procedure. After the system temperature of the module was optimized, a higher synthesis yield of 11C-CH3I (90.2 ±2.5)% was got, and 100% success rate of the synthesis was obtained at the same time. The synthesis time was 11min,and the radiochemical purity of the precursor was over 98%. Thus optimization of the system can lead to producing 11C-CH3I with higher and more stable yield.  
        关键词：11C-CH3I;Radiosynthesis;Optimization;PET   
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        发布时间：2021-03-12
      • DING Jianguo 1,2 LIU Songqiang1 1
        Issue 5, (2006)
        摘要：The Expermental Physics and Industrial Control System(EPICS) is a distributed control system based on “Standard Model”. In this paper we introduce the EPICS architecture, Runtime database, Channel Access protocol on TCP/IP as well as the network technologies to construct an EPICS control network. A developed generic EPICS de- vice/driver support for network devices is briefly described.  
        关键词：EPICS;TCP/IP;Network technology;Device/driver support   
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        发布时间：2021-03-12
      • JING Lan1 ZHU Haijun2 ZHANG Shuocheng1 WANG Dan1 QIAO Weimin1 1
        Issue 5, (2006)
        摘要：There are many fields and environments to be monitored in the HIRFL-CSR control system. The field in- telligent equipment based on MCU is designed, the system operational principle, hardware configuration and software block diagram are expatiated, and the function of the monitor system and its method of realization are described. The system has advantages such as friendly interface,low cost of design and simple operation, and satisfactory test results have been achieved.  
        关键词：Monitor system;Accelerator;Camera;MCU   
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        发布时间：2021-03-12
      • DING Xianli1,2 WANG Jinchuan1 QI Huirong1,2 XIAO Guoqing1 XIAO Zhigang1 XU Hushan1 SUN Zhiyu1 XU Zhiguo1 WU lijie1,2 HU Zhengguo1 GUO Zhongyan1 1
        Issue 5, (2006)
        摘要：This paper presents a series of tests of a detector unit which will be used in a fast, accurate, convenient and inexpensive medical diagnostic instrument for tumor——Micro Positron Emission Tomography (Micro-PET). The structure of the detector unit, its network of readout, the electronics and the data acquisition system are described. The position resolution reaches 1.02 mm. The ratio of the anode output maximum to minimum given by the 64 chan- nels of H8500 is 3.1, demonstrating a rather good uniformity.  
        关键词：BGO crystal;Multi-anode photomultiplier;Micro-PET;Electronic system   
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        发布时间：2021-03-12
      • CHU Chengsheng HUANG Ruiliang LIU Xiaoya HAO Fanhua GONG Jian HU Guangchun XIANG Yongchun ZHANG Jianhua
        Issue 5, (2006)
        摘要：The principle of alarm in the course of nuclear monitoring is introduced. The false alarm probability is de- fined. The alarm false probability of the nuclear monitoring system in a nuclear storeroom was calculated and meas- ured experimentally under different alarm thresholds. Origin of the difference between the calculated probability and the measured probability was analyzed.  
        关键词：False alarm probability;Nuclear monitoring;Alarm threshold   
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        发布时间：2021-03-12
      • LI Suqin1,2 SU Hong1 LI Yong1,2 QIAN Yi1,2 PENG Yu1,2 DONG Chengfu1 LI Xiaogang1 MA Xiaoli1 1
        Issue 5, (2006)
        摘要：A CPLD-based long-duration pulse generator, which can generate singular or continuous pulse with ul- tra-low repetition rate /long cycle, is introduced in this paper. The cycle (T) of output pulses generated by this genera- tor can be selected in a range from Tmin=1 ms to Tmax>1000 s. Also, the width of the output pulse can be adjusted from 1/1000 cycle to 999/1000 cycle stepped by 1/1000 cycle. Accuracy of the repetition rate(f) of output pulses is <0.02‰,and the long-term instability of is within ±0.01‰. There are two modes selectable for output pulses, singular pulse output and repetitive pulse output, which can be set by a two-position switch. When the singular pulse output mode is selected, only one pulse can be generated each time by pressing an external control push-button. This pulser can provide both TTL / TTL output signals and NIM / NIM output signals. The risetime of the NIM output signal is tr<4ns and the falltime is tf<4ns. We use CPLD to construct the main circuits. Compared with the circuits constructed by TTL devices, the new pulse generator has features such as less components, lower cost and lower dis- sipation.  
        关键词：Complex programmable logic device;Ultra-low repetition rate;Long-duration pulse width;Signals;Generator   
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        发布时间：2021-03-12
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