The purpose of the presented work is to synthesize 99Tcm-labeled dopamin D2 receptor imaging agent 2-{1-[(1-Ethoxycarbonyl-2-mercapto-ethylamino)-methyl]}-3-{4-[(1 -ethyl pyrrolidin-2-ylmethyl)-carbamoyl]-3- methoxy-5-bromo-phenylamino}-propylamino)-3-mercapto-propionic acid ethyl ester (99Tcm-m-Br-p-EBZM). The ECD was coupled with the benzamide derivative

N-[(1-ethyl-2-pyrrolidinealkyl)methyl]-4-acetylamino-5-bromium- 2- methyloxygen- benzol formamide

to yield m-Br-p-EBZM. The labeling compound was prepared through two steps of exchange labeling with 99Tcm-glucohetonate

and its stability was observed. Results show that m-Br-p-EBZM was synthesized for the first time

and was successfully labeled with 99Tcm with 98% of radiochemical purity

high stability and good liposolubility. Hence 99Tcm-m-Br-p-EBZM may become a potential dopamine D2 receptor imaging agent.