摘要:Phase analysis of biventricular radionuclide gated studies were carried out in 20 patients with right bundle branch block (RBBB) and in 5 left bundle branch block (LBBB), all without significant abnormalities of hemodynamic or ventricular wall motion. The results of this study indicated that the MRV, the △M(LV-RV)and the △Latest in 20 RBBB patients are significantly different from those of the normal patients. Likely, the MLV, the △M (LV-RV) and the △Latest in 5 LBBB patients are also different from those of the normal patients. The ventricular phase with BBB is obviously delayed, they are correlated very well with the EKG(100%). This report fully indicated that the phase analysis on Bundle Branch Block (BBB) is superior to the ordinary EKG and it is possible to study further on electrophysiology.
Ding Yuansheng Yi Ningyu Wang Yongqing Dai Xiangdong Xia Zongqin
Issue 5, (1991)
摘要:Sarsasapogenin was extracted from the Chinese herb Zhimu and its pharmacological action was compared with ZM decoction (ZM) in "Hyperthyroid" mice. 125I-Pindoiol binding assay revealed that the maximum binding capacity (RT) of brain beta-adrenoceptors of the models was significantly higher than normal and that repeated oral administrations of either ZM or SAR reduced the elevated RT to nearly normal. The peak value of plasma cAMP after a single dose of isoproterenol (ISO) was also significantly higher in the models than in control. Again oral administrations of either ZM or SAR reduced the response of plasma cAMP to ISO to nearly normal. However, in vitro competitive binding assay indicated that neither SAR nor its succinyl derivative had any direct binding reaction with beta adrenoceptors. It is therefore concluded that SAR is an important component of Zhimu and the mechanism of its "Yin-tonic" action is probably a down-regulation of the beta-adrenoceptors rather than direct occupation of receptor binding sites.
摘要:Bz-MAG3 was synthesized by reaction of triglyceride with chloroacetyl chloride followed by treatment with sodium thiobenzoate. The product was labelled with 99mTc and tested on rabbits for renal imaging characters. The results obtained were similar to those reported in literature.
Deng Shouzhen Lin Xiangtong He Wanting Zhang KailiZhang Jinming Kuai Dayu
Issue 5, (1991)
摘要:The refollow-up has been carried out in hypothyroidism caused by 131I treatment for Graves disease. The serum HS-TSH(IRMA), FT3, TSH(RIA), TT3, TT4, FT4I, MCA, TGA, Cholesterol and Triglyceride has been measured in 26 patient after 131I treatment for 9.5 yea.rs in average. At the same time TRH stimulation test was also performed, and the clinical symptoms and signs assessed. The results showed that TSH is the most sensitive criterion for hypothyroidism, followed by Cholesterol and FT4I. The occurrence of hypo-thyroidism may be related to the presence of thyroid antibody as demonstrated by the elevation of serum MCA, TGA. Therefore measurement of serum TSH, FT4I and Cholesterol during long term follow-up is beneficial for early diagnosis of hypothyroidism and evaluating the effect of subtitution treatment.
摘要:131I-Cholylglycyltyrosine (CGT) was used for the study of radiolocalization and targeting therapy in nude rats bearing human hepatocellular carcinoma (HCC) (nude rat-HCC). The nude rats were sacrificed at various intervals after intravenous injection of 131I-CGT, and radioactivity in major organs was determined. The uptake rate of 121I-CGT in tumor was remarkably higher than that of other tissues, especially on the phase of 24 hours. Tumor imaging was clearly observed 24 hours after the injection in all of the three rats. Dynamic scanning in nude rat-HCC model showed that 131I-CGT can be selectively taken up by hepatoma, and detained up to 7 days. Of the six rats treated, complete remission was observed in one rat three months later, while partial remission observed in the others.
摘要:This paper reported the study of quantitative analysis of bone imaging by computer in 60 cases with malignant tumor. The bor.e imaging were obtained 3 hours after the injection of 99mTc-MDP. The ratio of counts between the skeletal lesions and its contralateral or surrounding side was calculated, designated as H value. Three kinds of H value were found: <l.5,1.5 to 2,> The results showed that quantitative analysis of skeletal image is more effective than the visual inspection.
摘要:The CPM of 3H-TdR incroporated into the xenografts of nude mice was measured with liquid scintillation counter and the results showed that the 3H-TdR incorporation was depressed by different anticancer agents available both in transplantable human glioma and resectable tumor samples transplanted into nude mice. It is suggested that the method used in this experiment may be used for anticancer drug screening assay in the future.
Hu Yaer Xia zongqin Bian Yijie Pan ZhenqiuPan Xiaohong Yi Ningyu
Issue 5, (1991)
摘要:A technique for the determination of the production and degradation rates of mouse brain M-receptors was established. The selective alkylating ager.t BCM was given in vivo to irreversibly inhibit the M-receptors and the 3H-QNB binding assay was used to monitor the time-related increase of newly synthesized receptors. A tracer kinetics mathematical model was used to calculate the parameters. The results of three separate experiments with Balb-C mice were close to each other, the average production rate being 37.34fmol/mg protein/h, the average degradation rate constant being 0.035/h, and the half-time being 19.82h. The significance of this technique in the study of the mechanism of pathological changes in brain M-receptors and drug actions was discussed.
Feng Jialin Shao Songsheng Lin YapingLiu Hongzhen Zou Meijun
Issue 5, (1991)
摘要:Human peripheral blood was exposed to various 60Co γ-ray with doses ranging from 0-7 Gy. The premature condensed chromosome (PCC) technique was used to study the yield of G1-PCC fragments. The direct visualization of chromosome aberrations in interphase has been examined. The frequency of chromosome breaks produced in G1-PCC of the lymphocytes was scored. The results was compared with the conventional cytogenetic assay. The yield of G1-PCC fragments immediately after exposure is fitted with the linear regression equation.
摘要:The paper describes the dose distributions for total body electron irradiation by Varian Clinac-20 linear accelerator and provides for clinical radiotherapy plan with more complete and useful dosimetric data and experiences. A scatter screen can be used to reduce the primary electron energy, control treatment depth and enhance the skin dose. While radiotherapy is restricted in a room with limited space, dual angled gantry multiple irradiation field technique is a (?) method to create a homogeneous dose distribution on patient’s surface. For those sites located in the electron beam shadows, boosting irradiation and dose monitoring are necessary. The preliminary clinical trials indicate these dosimetric data and experiences are valid and feasible.
摘要:The BMC and BMD of the postmenopause osteoporotic patients, the diabetic patients and the relevant control group have been measured. The total number of subjects were 478 cases. Some factors of effect on bone mineral content were preliminary studied and the relationship between the BMC and the state of these diseases, such as the cure and course of these diseases were also discussed.
摘要:In this report we studied the effects of a chinese herb - Scutellarine on ANP level in main organs of rats by RIA, and examined its pharmacological action through vagotomy and atropinization on rats experiment, the ANP changes has been observed in main organs of those rats also. It demonstrated that Scutellarine can stimulate the secretion of ANP in rats and is related to the afferent nerve of its vagus nerve.
Li Ming Liu Honggang Xue Fangping Liu Yongchang Lin Xiangtong
Issue 5, (1991)
摘要:A rapid method for the measurement of radiopurity of imaging agents in five minutes was estabished. The thin layer chromatography of imaging agent is examined by dynamic acquisition of SPECT which provides a effective, useful and rapid method for the quality control of imaging agents in clinical practice.
摘要:In this paper the separation of the radioactive components in 99Tc-HMDP-NaBH4 label system both by anion exchange HPLC and ion pair HPLC is described. It is discovered that there are at least four different 99Tc compounds or compounds with different valency. The radioactivity of the main peak reaches about 90% of total radioactivity.
Chen Lianxiang Wang Xinhui Jin Yangsheng Zhang QinglingHuang Jianqiang
Issue 5, (1991)
摘要:A 133Xe rebreathing system is described for performing lung ventilation. The system is designed mainly for supply and disposition of 133Xe gas to be used for pulmonary function studies. The measurement and control of radioactivity concentration of 133Xe gas made in spirometer. The air sample of the system can be also analyzed for concentration of CO2 and O2.