Radiolocalization and targeting therapy using <sup>131</sup>I-CGT in nude rats bearing human hepatocellular carcinoma

Yu Zhuyuan Tang Zhaoyou

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Radiolocalization and targeting therapy using ¹³¹I-CGT in nude rats bearing human hepatocellular carcinoma

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- Radiolocalization and targeting therapy using ¹³¹I-CGT in nude rats bearing human hepatocellular carcinoma
- NUCLEAR TECHNIQUES Issue 5, (1991)
- 作者机构：
  
  1. 上海医科大学肝癌研究所
  2. 中山医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：01 May 1991
- 稿件说明：
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[1]余竹元,汤钊猷,钱峰,赵惠扬.~(131)Ⅰ-CGT在裸大鼠人肝癌模型中的放射性定位及实验治疗的研究[J].核技术,1991(05):273-276.

Yu Zhuyuan Tang Zhaoyou. Radiolocalization and targeting therapy using ¹³¹I-CGT in nude rats bearing human hepatocellular carcinoma[J]. Nuclear techniques, 1991, (5): 273-276.
[1]余竹元,汤钊猷,钱峰,赵惠扬.~(131)Ⅰ-CGT在裸大鼠人肝癌模型中的放射性定位及实验治疗的研究[J].核技术,1991(05):273-276. DOI：

Yu Zhuyuan Tang Zhaoyou. Radiolocalization and targeting therapy using ¹³¹I-CGT in nude rats bearing human hepatocellular carcinoma[J]. Nuclear techniques, 1991, (5): 273-276. DOI：

摘要

131

I-胆酰甘氨酰酪氨酸（CGT）被用于裸大鼠人肝癌放射性定位和实验治疗的研究。在静注

131

Ⅰ—CGT后所定时间内处死裸大鼠

并测定其主要脏器的放射性。

131

Ⅰ-CGT在肿瘤中的摄取率显著地高于其他组织

特别在24h时相。注射24h后

在3只大鼠中均可见清晰的肿瘤显像。裸大鼠肝癌模型的动态扫描表明

肝癌能选择性地摄取

131

I-CGT

并滞留达7天。经治疗的6只大鼠中

3个月后观察

其中1只鼠的肿瘤完全消退

其余的部分消退。

Abstract

131I-Cholylglycyltyrosine （CGT） was used for the study of radiolocalization and targeting therapy in nude rats bearing human hepatocellular carcinoma （HCC）（nude rat-HCC）. The nude rats were sacrificed at various intervals after intravenous injection of 131I-CGT

and radioactivity in major organs was determined. The uptake rate of 121I-CGT in tumor was remarkably higher than that of other tissues

especially on the phase of 24 hours. Tumor imaging was clearly observed 24 hours after the injection in all of the three rats. Dynamic scanning in nude rat-HCC model showed that 131I-CGT can be selectively taken up by hepatoma

and detained up to 7 days. Of the six rats treated

complete remission was observed in one rat three months later

while partial remission observed in the others.

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Radiolocalization and targeting therapy using 131I-CGT in nude rats bearing human hepatocellular carcinoma

DOI：

摘要

Abstract

关键词

Keywords

references

Radiolocalization and targeting therapy using ¹³¹I-CGT in nude rats bearing human hepatocellular carcinoma