浏览全部资源
扫码关注微信
新型水等效液体闪烁体的研究
Study on a new water equivalent liquid scintillator
- 核技术 2018年41卷第10期 文章编号：100203
- 作者机构：
1.苏州大学 放射医学与防护学院 苏州 215123
2.江苏省高校放射医学协同创新中心 苏州 215123
- 作者简介：
[ "王君辉, 女, 1992年出生, 2014年毕业于徐州医科大学, 现为苏州大学硕士研究生, 研究方向为医学物理", "WANG Junhui, female, born in 1992, graduated from Xuzhou Medical University in 2014, master student in Soochow University, focusing on medical physics" ]
张保国, E-mail:bgzhang@suda.edu.cn ZHANG Baoguo, E-mail:bgzhang@suda.edu.cn
- 基金信息：国家自然科学青年基金(11605120);苏州市科技发展计划（科技设施）项目(SZS2017021)
DOI：10.11889/j.0253-3219.2018.hjs.41.100203
中图分类号： TL99收稿日期：2018-01-29，
修回日期：2018-05-19，
纸质出版日期：2018-10-10
- 稿件说明：
移动端阅览
王君辉, 张保国, 文万信, 等. 新型水等效液体闪烁体的研究[J]. 核技术, 2018,41(10):100203
Junhui WANG, Baoguo ZHANG, Wanxin WEN, et al. Study on a new water equivalent liquid scintillator[J]. Nuclear techniques, 2018, 41(10): 100203
王君辉, 张保国, 文万信, 等. 新型水等效液体闪烁体的研究[J]. 核技术, 2018,41(10):100203 DOI： 10.11889/j.0253-3219.2018.hjs.41.100203.
Junhui WANG, Baoguo ZHANG, Wanxin WEN, et al. Study on a new water equivalent liquid scintillator[J]. Nuclear techniques, 2018, 41(10): 100203 DOI： 10.11889/j.0253-3219.2018.hjs.41.100203.
摘要
本研究旨在研制具有水等效性的液体闪烁体材料，以用于肿瘤放射治疗和辐射防护的剂量测量。实验中的液体闪烁体由十二烷基苯、二甲基亚砜（Dimethyl sulfoxide，DMSO）、曲拉通X-100（Triton X-100）、2，5-二苯基恶唑（2，5-Diphenyloxazole，PPO）和1，4，双2（5苯基恶唑）苯（1，4Bis（5-phenyloxazol-2-yl）benzene，POPOP）组成。首先根据有效原子序数、电子密度公式和蒙特卡罗程序GEANT4（GEometry And Tracking 4）计算上述材料具有良好水等效性时的最佳浓度配比；根据最佳浓度配比配制液体闪烁体，并利用生物学X射线辐照仪和多道谱仪分别测量其水等效性能和辐射发光性能。研究结果表明：配制1 L新型液体闪烁体的最优配方为0.09 L的DMSO、0.36 L的十二烷基苯、0.55 L的Triton X-100、4 g·L
-1
的PPO和0.2 g·L
-1
的POPOP。上述配方液体闪烁体材料具有良好的水等效性（吸收剂量与水对应的吸收剂量比值几乎为1，最大相差在0.1%以内），并且保留了液体闪烁体的辐射发光功能（发光效率为一般商用液体闪烁体的1/3）。研制的新型液体闪烁体可用作肿瘤放射治疗和辐射防护中的测量体模材料和剂量探测器。
Abstract
Background
2
With the development of radiotherapy technology
new challenges have been posed for radiation dose planning techniques. Liquid scintillators have been studied a lot for dose measurement
its luminous intensity is proportional to the deposition energy
which can be used to measure the absorbed dose.
Purpose
2
This study aimed to develop water-equivalent liquid scintillator materials for the measurement of absorbed dose in tumor radiotherapy and radioprotection.
Methods
2
The liquid scintillator used in this experiment is composed of dodecylbenzene
dimethyl sulfoxide (DMSO)
Triton X-100
2
5-diphenyloxazole (PPO) and 1
4-bis-(5-phenyloxazol-2-yl)-benzene (POPOP). First
the best concentration ratio of the above materials with good water-equivalence was calculated according to the effective atomic number
electron density formula and Monte Carlo program GEANT4 (GEometry And Tracking 4). The liquid scintillator was prepared according to the optimal concentration ratio
and its water-equivalence as well as radioluminescent properties were verified using the biological X-ray irradiance and multi-channel spectrometer respectively.
Results
2
The results showed that the optimal component of 1 L liquid scintillator is 0.09 L of DMSO
0.36 L of dodecylbenzene
0.55 L of Triton-X
4 g·L
-1
of PPO and 0.2 g·L
-1
of POPOP. The as-prepared liquid scintillator material has good water-equivalence (the ratio of absorbed dose to water is close to 1 with difference less than 0.1%) and retains radioluminescent property (its luminous efficiency is 1/3 of that of a typical commercial liquid scintillator).
Conclusion
2
This new liquid scintillator can be used as a phantom and dose detector in cancer radiotherapy and radioprotection.
关键词
Keywords
references
Y Nishimura , R Komaki . Intensity-modulated radiation therapy , Institute of Physics Pub , 2001 . 845 - 846 . DOI: 10.1007/978-4-431-55486-8 http://doi.org/10.1007/978-4-431-55486-8 .
D Cusumano , M Fumagalli , F Ghielmetti , . A 53-sum signal film dosimetry:a novel approach for high dose patient specific quality assurance with Gafchromic EBT3 . Physica Medica , 2016 . 32 16 DOI: 10.1016/j.ejmp.2016.01.057 http://doi.org/10.1016/j.ejmp.2016.01.057 .
C Xie , X Cong , S Xu , . The Dose effect of isocenter Selection during IMRT dose verification with the 2D chamber array . Chinese Journal of Medical Instrumentation , 2015 . 39 ( 3 ): 222 DOI: 10.3969/j.issn.1671-7104.2015.03.019 http://doi.org/10.3969/j.issn.1671-7104.2015.03.019 .
Venning A, Chandroth M, Chick B, et al . Dosimetric validation study of a flattening filter free SABR treatment by use of a normoxic PAG gel dosimeter with MRI readout[C]. Journal of Physics Conference Series, 2017: 012039. DOI: 10.1088/1742-6596/847/1/012039 http://dx.doi.org/10.1088/1742-6596/847/1/012039 .
R Onizuka , F Araki , T Ohno , . SU-F-T-364:Monte Carlo-dose verification of volumetric modulated arc therapy plans using AAPM TG-119 test patterns . Medical Physics , 2016 . 43 ( 6 ): 3547 DOI: 10.1118/1.4956549 http://doi.org/10.1118/1.4956549 .
G Delaney , W Beckham , M Veness , . Three-dimensional dose distribution of tangential breast irradiation:results of a multicentre phantom dosimetry study . Radiotherapy & Oncology Journal of the European Society for Therapeutic Radiology & Oncology , 2000 . 57 ( 1 ): 61 - 68 . DOI: 10.1016/S0167-8140(00)00262-0 http://doi.org/10.1016/S0167-8140(00)00262-0 .
L Beaulieu , S Beddar . Review of plastic and liquid scintillation dosimetry for photon, electron, and proton therapy . Physics in Medicine & Biology , 2016 . 61 ( 20 ): R305 DOI: 10.1088/0031-9155/61/20/R305 http://doi.org/10.1088/0031-9155/61/20/R305 .
A Dimitriadis , I S Patallo , I Billas , . Characterisation of a plastic scintillation detector to be used in a multicentre stereotactic radiosurgery dosimetry audit . Radiation Physics & Chemistry , 2017 . 140 373 - 378 . DOI: 10.1016/j.radphyschem.2017.02.023 http://doi.org/10.1016/j.radphyschem.2017.02.023 .
A S Beddar . Water equivalent plastic scintillation detectors in radiation therapy . Radiation Protection Dosimetry , 2006 . 120 ( 1-4 ): 1 - 6 . DOI: 10.1093/rpd/nci694 http://doi.org/10.1093/rpd/nci694 .
D Robertson , S Beddar , D Robertson , . 3D liquid scintillation dosimetry for photons and protons , Scintillation Dosimetry , 2016 . DOI: 10.1201/b19491-19 http://doi.org/10.1201/b19491-19 .
D White . An analysis of the Z-dependence of photon and electron interactions . Physics in Medicine and Biology , 1977 . 22 ( 2 ): 219 - 228 . DOI: 10.1088/0031-9155/22/2/003 http://doi.org/10.1088/0031-9155/22/2/003 .
D R White . Effective atomic numbers in the formulation of tissue substitute materials for photons . Radiation Research , 1978 . 76 ( 1 ): 23 - 31 . DOI: 10.2307/3574924 http://doi.org/10.2307/3574924 .
李 士骏 . 电离辐射剂量学 , : 北京 原子能出版社 , 1981 .
Shijun LI . Ionizing radiation dosimetry , : Beijing Atomic Energy Press , 1981 .
J F Carrier , L Archambault , L Beaulieu , . Validation of GEANT4, an object-oriented Monte Carlo toolkit, for simulations in medical physics . Medical Physics , 2004 . 31 ( 3 ): 484 - 492 . DOI: 10.1118/1.1644532 http://doi.org/10.1118/1.1644532 .
0
浏览量
24
下载量
0
CSCD
- 网络PDF下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
AI问答- 地址：上海市嘉罗公路2019号 邮编：201800
- 联系电话：021-39194977 Email：LHB@sinap.ac.cn
- 技术支持由北京北大方正电子有限公司提供 沪ICP备05005479号-1
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
- 总访问量：880473
