GATE在计算人体体素模型光子剂量转换系数的应用分析

崔甜甜; 张书源; 王一迪; 李占鹏; 孙亮

doi:10.11889/j.0253-3219.2018.hjs.41.040501

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GATE在计算人体体素模型光子剂量转换系数的应用分析

核物理、交叉学科研究 | 更新时间：2021-05-19

- GATE在计算人体体素模型光子剂量转换系数的应用分析
- Application of GATE in calculating photon dose conversion coefficient of human voxel phantom
- 核技术 2018年41卷第4期文章编号：040501
- 作者机构：
  
  苏州大学医学部放射卫生与防护学院苏州 215123
- 作者简介：
  
  [ "崔甜甜, 女, 1990年出生, 2012年毕业于郑州大学, 现为硕士研究生, 研究领域为蒙特卡罗方法在辐射防护中的应用", "CUI Tiantian, female, born in 1990, graduated from Zhengzhou University in 2012, master student, focusing on the application of Monte-Carlo method in radiation protection" ]
  孙亮, E-mail:SLHMZ@126.com SUN Liang, E-mail: SLHMZ@126.com
- 基金信息：
  
  国家自然科学基金(11575124);国际热核聚变实验堆计划专项(2014GB112006)
- DOI：10.11889/j.0253-3219.2018.hjs.41.040501
  中图分类号： TL99
- 收稿日期：2017-12-07，
  
  修回日期：2018-01-24，
  
  纸质出版日期：2018-04-10
- 稿件说明：
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崔甜甜, 张书源, 王一迪, 等. GATE在计算人体体素模型光子剂量转换系数的应用分析[J]. 核技术, 2018,41(4):040501

Tiantian CUI, Shuyuan ZHANG, Yidi WANG, et al. Application of GATE in calculating photon dose conversion coefficient of human voxel phantom[J]. Nuclear techniques, 2018, 41(4): 040501
崔甜甜, 张书源, 王一迪, 等. GATE在计算人体体素模型光子剂量转换系数的应用分析[J]. 核技术, 2018,41(4):040501 DOI： 10.11889/j.0253-3219.2018.hjs.41.040501.

Tiantian CUI, Shuyuan ZHANG, Yidi WANG, et al. Application of GATE in calculating photon dose conversion coefficient of human voxel phantom[J]. Nuclear techniques, 2018, 41(4): 040501 DOI： 10.11889/j.0253-3219.2018.hjs.41.040501.

摘要

分析GEANT4应用发射断层（GEANT4 Application for Tomographic Emission，GATE）在模拟人体体素模型剂量转换系数的应用，为计算基于体素模型的光子辐射场中的剂量提供一种新路径。GATE是基于GEANT4开发并广泛应用于模拟正电子发射断层成像（Positron Emission Tomography，PET）、单光子发射计算机断层成像（Single Photon Emission Computed Tomography，SPECT）等成像系统以及放射治疗的蒙特卡罗模拟软件。用自编的MATLAB程序将人体体素模型KTMAN-2的体素数据逆转为断层影像（Computed Tomography，CT），再由VV软件将CT转换为GATE体素模型文件，在GATE和MCNPX（Monte Carlo N-Particle eXtended）中模拟6种标准照射方式下、0.01~10 MeV能量范围内23种单能光子在人体内的输运，得到一系列的光子器官剂量转换系数，将两者的计算结果进行对比，并将结果和ICRP 74、ICRP 116号出版物的推荐值进行比较。GATE和MCNPX的计算结果具有很好的一致性，除质量很小的器官（垂体、扁桃体、甲状腺等），其它器官的差异都在3%以内；对于某些器官在某些照射条件下，所得结果和ICRP 74、ICRP 116号出版物的推荐值一致，但在某些照射条件本文结果与ICRP 74、ICRP 116出版物的推荐值存在较大差异。GATE为基于体素模型的剂量计算提供了一种新方法；本文计算的剂量转换系数对于分析亚洲人个体与ICRP参考人之间光子剂量转换系数的差异具有重要意义。

Abstract

Background

The GEANT4 application for tomographic emission (GATE) Monte Carlo simulation platform based on GEANT4 toolkit has come into widespread use for simulating positron emission computed tomography (PET)

single photon emission computed tomography (SPET) imaging systems and is potentially useful for a board range of simulations

including those where the absorbed dose is the principal observable.

Purpose

This paper aims to analyze the application in calculating the dose conversion coefficient of human voxel phantom

and provides a new solution for calculating the dose of voxel phantom in photon radiation field.

Methods

The voxel data of human voxel phantom KTMAN-2 was reversed to CT by self-compiled MATLAB program

and CT was converted into GATE voxel model file by VV software. To obtain photon dose conversion coefficients

GATE and MCNPX were used to simulate the photon transport for 23 monoenergetic photon beams from 0.01 MeV to 10 MeV under six standard irradiation geometries in human voxel phantom

and the results of GATE and MCNPX were compared and they were also compared with the recommended values in the ICRP 74 and ICRP 116 publication.

Results

Good agreement was found for both GATE and MCNPX

the difference of organs within 3% except small organs (pituitary

tonsils

thyroid

etc.); the calculated values were reasonable in comparison with the values from ICRP 74 and ICRP 116

but under some irradiation conditions

differences are observed in calculated values of KTMAN-2 compared with ICRP 74 and ICRP 116.

Conclusion

GATE provides a new method for dose calculation based on voxel model. The dose conversion coefficient calculated in this paper would be of great significance for analyzing the difference in photon dose conversion coefficients between Asian male and ICRP male reference phantom.

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references

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