基于细胞自噬机制的健康科学研究进展

林承列; 李江; 周宜; 孙艳红; 王丽华; 胡钧; 樊春海

doi:10.11889/j.0253-3219.2017.hjs.40.020501

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基于细胞自噬机制的健康科学研究进展

核化学、放射化学、放射性药物和核医学 | 更新时间：2021-05-19

- 基于细胞自噬机制的健康科学研究进展
  封面论文
- Autophagy-based mechanistic understanding of healthcare science
- 核技术 2017年40卷第2期文章编号：020301
- 作者机构：
  
  1.中国科学院上海应用物理研究所微观界面物理与探测重点实验室物理生物学研究室上海同步辐射光源生物成像中心上海 201800
  2.成都中医药大学基础医学院成都 611137
- 作者简介：
  
  [ "林承列, 男, 1987年出生, 2012年毕业于成都中医药大学, 现为成都中医药大学与中国科学院上海应用物理研究所联合培养硕士研究生, 研究方向为针灸的细胞信号通路", "LIN Chenglie, male, born in 1987, graduated from Chengdu University of Traditional Chinese Medicine in 2012, master student, focusing on molecular signal pathways related to acupuncture" ]
  李江, E-mail:lijiang@sinap.ac.cn LI Jiang, E-mail:lijiang@sinap.ac.cn
  樊春海, E-mail:fanchunhai@sinap.ac.cn FAN Chunhai, E-mail:fanchunhai@sinap.ac.cn
- 基金信息：
  
  国家自然科学基金(2013CB932802);国家自然科学基金(31371015)
- DOI：10.11889/j.0253-3219.2017.hjs.40.020501
  中图分类号： Q274
- 收稿日期：2016-10-28，
  
  修回日期：2016-11-14，
  
  纸质出版日期：2017-02-10
- 稿件说明：
移动端阅览
林承列, 李江, 周宜, 等. 基于细胞自噬机制的健康科学研究进展[J]. 核技术, 2017,40(2):020301

Chenglie LIN, Jiang LI, Yi ZHOU, et al. Autophagy-based mechanistic understanding of healthcare science[J]. Nuclear techniques, 2017, 40(2): 020301
林承列, 李江, 周宜, 等. 基于细胞自噬机制的健康科学研究进展[J]. 核技术, 2017,40(2):020301 DOI： 10.11889/j.0253-3219.2017.hjs.40.020501.

Chenglie LIN, Jiang LI, Yi ZHOU, et al. Autophagy-based mechanistic understanding of healthcare science[J]. Nuclear techniques, 2017, 40(2): 020301 DOI： 10.11889/j.0253-3219.2017.hjs.40.020501.

摘要

自噬（autophagy）是细胞对自身组件进行降解与回收的自然过程，与人类健康高度相关。很多疾病都伴随着自噬的异常。本文回顾了国内外近年来在自噬与健康关系领域的研究，包括自噬与癌症、神经退行性疾病等疾病的关系。并且回顾了对人体健康有明显影响的电离辐射、体育锻炼、针灸、按摩等物理刺激对细胞自噬的调控作用，从自噬的角度对这些作用的分子机制进行了讨论。最后，对于自噬调控在未来的医疗保健中的潜在价值进行了展望。

Abstract

Background:

Autophagy is a natural process in cells for self-digestion of intracellular elements

which is highly related to human health.

Purpose:

To better understand the relationship between autophagy and health issues like cancer

neurodegeneration and aging

we reviewed recent studies on this topic in this paper. We also reviewed some physical stimulations that have effects on health while have been verified capable to induce autophagy

including ionic radiation

physical exercise

acupuncture and massage.

Results & Conclusion:

We discussed the molecular mechanisms of their effects from the point of autophagy

and looked to the future of healthcare where the regulation of autophagy may be heavily involved.

关键词

Keywords

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