国产模块酸水解全自动化合成<sup>18</sup>F-FDG

李海峰; 张晓军; 李云钢; 张锦明

doi:10.11889/j.0253-3219.2016.hjs.39.080301

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国产模块酸水解全自动化合成¹⁸F-FDG

核化学、放射化学、放射性药物和核医学 | 更新时间：2021-05-24

- 国产模块酸水解全自动化合成¹⁸F-FDG
- Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module
- 核技术 2016年39卷第8期文章编号：080301
- 作者机构：
  
  1.江西省肿瘤医院核医学科南昌 330029
  2.中国人民解放军总医院核医学科北京 100853
- 作者简介：
  
  [ "李海峰, 男, 1981年出生, 2011年于南昌大学获硕士学位, 化学师, 主要从事放射性药物的合成与标记", "LI Haifeng, male, born in 1981, graduated from Nanchang University with a master's degree in 2011, chemist, mainly engaged in radiopharmaceuticals' synthesis and label" ]
  张锦明, E-mail:zhangjm301@163.com ZHANG Jinming, E-mail: zhangjm301@163.com
- 基金信息：
  
  军队医疗机构制剂标准提高项目(No.14ZJZ2101)
- DOI：10.11889/j.0253-3219.2016.hjs.39.080301
  中图分类号： TL92+3
- 收稿日期：2016-04-03，
  
  修回日期：2016-04-29，
  
  纸质出版日期：2016-08
- 稿件说明：
移动端阅览
李海峰, 张晓军, 李云钢, 等. 国产模块酸水解全自动化合成¹⁸F-FDG[J]. 核技术, 2016,39(8):080301

Haifeng LI, Xiaojun ZHANG, Yungang LI, et al. Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module[J]. Nuclear techniques, 2016, 39(8): 080301
李海峰, 张晓军, 李云钢, 等. 国产模块酸水解全自动化合成¹⁸F-FDG[J]. 核技术, 2016,39(8):080301 DOI： 10.11889/j.0253-3219.2016.hjs.39.080301.

Haifeng LI, Xiaojun ZHANG, Yungang LI, et al. Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module[J]. Nuclear techniques, 2016, 39(8): 080301 DOI： 10.11889/j.0253-3219.2016.hjs.39.080301.

摘要

FDG

F-脱氧葡萄糖（

F-FDG）合成模块一般仅能采用一种工艺进行生产，改变工艺条件会对产品质量造成影响，本文旨在解决此问题，同时优化生产工艺。本研究对国产碱水解FDG合成模块进行改进，省去自动加碱装置及在柱水解部件。通过研究亲核反应时间、盐酸量、水解时间及残留溶剂等影响因素，寻求酸水解合成

F-FDG最优化的合成工艺。从淋洗18F-离子至终产品

F-FDG的总合成时间为27 min，合成效率为60.27%±2.29%（

=37，未校正效率），产品放化纯度大于98%，产量（29.15±3.09）GBq（

=37）。改进的合成工艺实现了自动化、稳定合成

F-FDG，产品满足临床需求，实现了两种不同工艺在同一模块上制备

F-FDG。

Abstract

Background:

The FDG

F-fluorodeoxyglucose (

F-FDG) synthesis module was obtained by one process of production generally. The adjusting of synthetic technology would have a significant influence on the quality of product.

Purpose:

In order to solve the problem and optimize the production process

in this paper

the domestic FDG synthesis module has been improved.

Methods:

The domestic FDG synthesis module of basic hydrolysis was optimized by removing the components of automatic alkali-adding and on-column hydrolysis. The influencing factors of synthesis process were discussed

including the time of nucleophilic reaction

the amount of HCl

the hydrolysis time and the residual solvents.

Results:

It took 27 min from

F-to final product of

F-FDG

and a radiochemical yield of 60.27%±2.29% (

=37

End of Synthesis (EOS)) was obtained. The radiochemical purity of

F-FDG was higher than 98% and the radioactivity was (29.15±3.09) GBq (

=37).

Conclusion:

The synthetic process was reliable and automated

and the product was suitable for clinical use. Finally

two different processes were used for synthesizing

F-FDG on the same module.

关键词

Keywords

references

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国产模块酸水解全自动化合成18F-FDG

Fully automated synthesis of 18F-FDG by acidic hydrolysis on domestic module

DOI：10.11889/j.0253-3219.2016.hjs.39.080301

摘要

Abstract

关键词

Keywords

references

国产模块酸水解全自动化合成¹⁸F-FDG

Fully automated synthesis of ¹⁸F-FDG by acidic hydrolysis on domestic module