Background: By changing the size or the morphology of Au nanostructures

they can absorb different wavelength light due to the localized surface plasmon resonance(LSPR).Because Au nanorods show good ability to transform light into heat(photothermal effect)

they have been wildly used to deliver the drugs and release them controllably.However

when applying such nanostructures for in vivo treatments

Au nanorods must have long aspect ratio which often make it hard to prepare heterogeneous nanostructures.Purpose: A new method to synthesize Au nanostructures with uniform size and to achieve long wavelength light absorbance is needed.This work attempts to synthesize such Au nanostructures by using bio-nano techniques.Methods: New nanostructures are prepared by growing Au nanoparticles on the surface of Au nanorods modified with DNA molecules.Results: Dumbbell-like Au nanostructures were prepared firstly.Its maximum absorbance locates at near ultraviolet region

which means that it can be used as a potential tool for the deep-skin photothermal treatment.Moreover

other two kinds of nanostructures

i.e.Au nanorods with Au splinter at two ends and sea urchin-like nanostructures

are also studied.Conclusions: We successfully fabricated novel Au nanostructures which can be used for drug delivery

surface-enhanced Raman spectroscopy and catalysis.