Background: Non-steroidal anti-inflammatory drug Indomethacin have been used in the treatment of fever

pain

inflammation and rheumatic disease.In recent years

some researches have confirmed that Indomethacin have the ability of assistant therapy on many kinds of malignant tumors

such as colon cancer

gastric cancer and lung cancer.Purpose: To evaluate the effect of Cisplatin combined with Indomethacin and Histamine-Indomethacin to Lewis lung cancer.Methods: 40 male Kunming mice were used to establish Lewis lung cancer model.They were randomly divided into four groups: Cisplatin treatment group

Cisplatin+Indomethacin treatment group

Cisplatin+Histamine-Indomethacin treatment group and control group.Each mouse was given the PET/CT imaging and taken orbital blood for 0.2 mL before and after the treatment.Histological detection was given.Results: Ratio of targets were significantly different after the treatment

especially in Cisplatin+Histamine-Indomethacin treatment group.Each group TNF-α levels were increased after treatment and the Cisplatin+Histamine-Indomethacin treatment group was the most obvious.There was no obvious difference in tumor inhibiting rates.Conclusions: The results showed that Cisplatin combined with Histamine-Indomethacin could inhibit tumor growth and promote apoptosis of tumor cells better.The changes of the ratio of targets could reflect the effect of the chemotherapy drugs earlier.