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上海医科大学华山医院
纸质出版日期:1991-05-01
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[1]邓守真,林祥通,何婉婷,张凯莉,张锦明,蒯大禹.~(131)Ⅰ治疗Graves病后远期并发甲减的再随访[J].核技术,1991(05):269-272.
Deng Shouzhen Lin Xiangtong He Wanting Zhang KailiZhang Jinming Kuai Dayu. Hypothyroidism caused by 131I treatment for Graves disease --A refollow-up[J]. Nuclear techniques, 1991, (5): 269-272.
作者在1985年对
131
I治疗Graves病后远期并发甲减随访的基础上
采用HS-TSH(IRMA)、FT
s
、TSH、TT
3
、TT
4
、FT
4
I、TRH兴奋试验及MCA、TGA、胆固醇、甘油三脂等项目测定
并结合临床症状、体征对26例(治疗年限平均9.5a)患者进行随访
通过对上述指标比较
指出TSH诊断符合率最高
胆固醇、FT
4
I其次
甲减的并发似与患者甲状腺抗体(MCA、TGA)存在有关
并认为
131
Ⅰ治疗后患者长期随访TSH、FT
4
I及胆固醇
有助于及早发现并发甲减和对甲减在替代治疗中病情控制的判断。
The refollow-up has been carried out in hypothyroidism caused by 131I treatment for Graves disease. The serum HS-TSH(IRMA)
FT3
TSH(RIA)
TT3
TT4
FT4I
MCA
TGA
Cholesterol and Triglyceride has been measured in 26 patient after 131I treatment for 9.5 yea.rs in average. At the same time TRH stimulation test was also performed
and the clinical symptoms and signs assessed. The results showed that TSH is the most sensitive criterion for hypothyroidism
followed by Cholesterol and FT4I. The occurrence of hypo-thyroidism may be related to the presence of thyroid antibody as demonstrated by the elevation of serum MCA
TGA. Therefore measurement of serum TSH
FT4I and Cholesterol during long term follow-up is beneficial for early diagnosis of hypothyroidism and evaluating the effect of subtitution treatment.
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