The authors reported the reactions of glycine

alycine and glycine ethyl esterwith pyridoxal chloride to form the base and the compound chelated with 99mTc in thepresence of SnCl2· 2H2O. The metabolism of this compound in vivo was alsoobserved. The influencing factors were studied and the best labelling procedures wereobtained. The animal experiment on 99mTc-SB-Gly indicated that this agent could berapidly excreted through the kidney into the urine after intravenous injection

withan excretory rate of 79.68± 6.66ID% in 30min via urine

a little bit lower than99mTc-DTPA （82.56 ± 6.88ID%）

but having a clear renal scintigraphy. Besides

theelimination of blood was rapid and the labelling compound had enough safety. Ininhibition experiments with probencid in rats

the urine excretion rate was notaffected

suggesting that this compound passed through by glomerular filtration.