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1. 中国科学院高能物理研究所
2. 北京医科大学第三附属医院
3. 中国科学院高能物理研究所北京医科大学第三附属医院
纸质出版日期:1998-07-01
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[1]刘年庆,刘鹏,徐清,邵涵如,刘平生,吴应荣,马东星,赵金坦.用多元统计方法和微束扫描技术分析急性镉中毒的鼠肾中微量元素的分布[J].核技术,1998(07):415-419.
LIU Nianqing LIU Peng XU Qing SHAO Hanru LIU Pingsheng WU Yingrong. Trace element distribution in kidney of rats treated with CdCl2 by multivariable statistics and micro-SXRF[J]. Nuclear techniques, 1998, (7).
[1]刘年庆,刘鹏,徐清,邵涵如,刘平生,吴应荣,马东星,赵金坦.用多元统计方法和微束扫描技术分析急性镉中毒的鼠肾中微量元素的分布[J].核技术,1998(07):415-419. DOI:
LIU Nianqing LIU Peng XU Qing SHAO Hanru LIU Pingsheng WU Yingrong. Trace element distribution in kidney of rats treated with CdCl2 by multivariable statistics and micro-SXRF[J]. Nuclear techniques, 1998, (7). DOI:
用同步辐射X荧光微束扫描技术测量了未经处理的、腹腔注射CdCl2的及注射后用新型的络合剂促排的兰组Wistar大鼠的肾切片。结果表明Cd主要分布在肾的皮质部分,而髓质部分含量很低。用多元素统计分析探讨了元素间的关系:在正常鼠肾中,元素分布基本上聚类成两大类,其中微量元素Cu、Zn.Mn和Se为一类。它们在肾中的分布有效强的共位性,处于平衡状态;急性中毒时,Cd与Se的距离最近,有较强的相互作用,其次是与Ca,此时元素的分类不明显,平衡被打乱;中毒后用新药促排的Se和Zn强相关并聚为一类,其它元素间的相关性变弱,元素基本上又趋于分为两类。
By using micro- scanning technique of SXRF (Synchrotron Radiation X-ray Fluorescence) combined with multivariable statistical analysis (correlation and hierarchi- cal cluster analysis)
the positional distributions of eleanens in the kidney tissues of three groups of Wistar rats i.e
the control
that treated by CdCl2 and that Cd exposed then treated with a new complex) were obtained. The results show that Cd is mainly distributed in the renal cortex of rats treated by CdCl2
while. the level of Cd in the renal medulla is very low or not detectable. The elements measured in renal cortex of the normal rats can be classified into two groups and Cu
Zn.
Mn and Se belong to the same group and have very strong co-locations. In acute CdCl2 poisoning
there is a very strong correlation between Cd and Se
and a secondly strong correlation between Cd and Ca. The classification is therefore different from that for the control. After administration of a new chelator
a very strong co-location and correlation can be observed between Zn and Se
and the classification of elements tends to return to the normal distribution.
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