90Y generator was made by absorption 90Sr-90Y equilibrium system to Dowex 50 resin. 90Y was obtained by elution with sodium citrate buffer solution. The 90Y was mixed with Biou-Rex 70 resin

high binding rate were achieved when the pH value was more than eight and the mixing duration was 4 h.90Y labelled resin was injected through hepatic artery catheter into the right lower lobe of liver in dog. The total blood concentration of 90Y was estimated to be 1% of total dose administered.After 2 weeks

X-CT showed that the administered liver lobe observed liquified necrosis and liver atrophy grossly

also liver cell die away extensive1y in pathological sections.These prelimenary findings suggested that with selective administration of hepatic artery catheterization

radiolabelled resin was an effective and safe radioinjury reagent

and can be used for tumor radiotherapy.