Nerve growth factor(NGF) was iodolabelled with chloramine-T method and its distribution and excretion in mice were investigated. The results showed that the highest levels were found in superior cervical ganglia
thyroid
bile
kidneys and adrenals between 20-30 min after injection
and the peak time in most tissues was also found at 20-30 min. About 72.55% of the injected dose was excreted in stool and urine
among them 65.6% was excreted in urine and only 7.0% in stool within 72h after intramuscular injection.