The feasibility and specificity of imaging of myocardial infarct with 99mTc-AMLA was reported. The first group of myocardial infarction（MI） rats were injected 99mTc-AMLA at 24h post MI. The second group were injected with 99mTc-N-IgG for control. For study of the influence of MI onset to uptake of 99mTc-AMLA

the third group with varied duration of MI from 4h to 14d was used.ID%/g and Infracted/Normal uptake ratio（IM/NM） were calculated. One in vitroheart of MI dog was imaged at 24 h after injection of 99mTc-AMLA. The results showed that the infarcted myocardium uptake of 99mTc-AMLA was higher than the normal myocardium. The IM/NM reached 6.68 at 8h in the first group

while non-specific IM/NM of 99mTc-N-IgG was only 1.42 （P<0.01）. There were no significant differences between the ratios of uptake of 99mTc-AMLA in any infarcted duration from 4h to 14d（P>0.05）. The in vitro myocardium imaging showed that the localization of 99mTc-AMLA in myocardium was the same as the blank area of triphenyltetrazolium chloride staining. It was concluded that 99mTc-AMLA is a myocardial imaging agent specific to MI. Thereby

it can be used as a useful infarct avid imaging reagent.