<sup>131</sup>I 碘化油在阻断左肝静脉时动脉栓塞的动物实验研究

蒋宁一; 王捷; 吕斌; 刘幸光

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¹³¹I 碘化油在阻断左肝静脉时动脉栓塞的动物实验研究

更新时间：2021-04-09

- ¹³¹I 碘化油在阻断左肝静脉时动脉栓塞的动物实验研究
- Experimental study of hepatic arterial embolization with 131I-lipiodol in temporary occlusion of the left hepatic vein
- 核技术 1997年第11期
- 作者机构：
  
  中山医科大学孙逸仙纪念医院
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： Q95-33
- 纸质出版日期：1997-11-01
- 稿件说明：
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[1]蒋宁一,王捷,吕斌,刘幸光.~(131)I 碘化油在阻断左肝静脉时动脉栓塞的动物实验研究[J].核技术,1997(11):43-46.

Jiang Ningyi Wang Jie Lu Bin Liu Xingguang. Experimental study of hepatic arterial embolization with 131I-lipiodol in temporary occlusion of the left hepatic vein[J]. Nuclear techniques, 1997, (11).
[1]蒋宁一,王捷,吕斌,刘幸光.~(131)I 碘化油在阻断左肝静脉时动脉栓塞的动物实验研究[J].核技术,1997(11):43-46. DOI：

Jiang Ningyi Wang Jie Lu Bin Liu Xingguang. Experimental study of hepatic arterial embolization with 131I-lipiodol in temporary occlusion of the left hepatic vein[J]. Nuclear techniques, 1997, (11). DOI：

摘要

用１３１Ｉ标记碘化油作为肝动脉栓塞剂，对小猪行左肝静脉阻断下左肝动脉栓塞。１３１Ｉ碘化油标记用交换催化反应法，标记率在９５％以上。术后定期作ＳＰＥＣＴ显像，通过图像了解肺／肝放射性计数比、全身放射性分布情况及核素体内衰变规律和病理变化。结果是肺／肝放射性计数比值于术后第１、３天明显降低，差别显著（Ｐ＜０．０５）。而术后第５、７、１４天的比值，两组之间无明显差别（Ｐ＞０．０５）。１３１Ｉ－碘化油体内有效半衰期４．５３天（中位数）。病理学检查，肝脏见散在斑点状小梗死灶，部分左叶包膜较增厚。镜下油栓处梗死灶凝固性坏死，纤维化改变。结果表明，暂时性阻断左肝静脉下行肝动脉１３１Ｉ碘化油栓塞，通过对肝血流动力学及肝内油栓分布的影响可提高栓塞效果，同时对急性肺栓塞也有一定的预防作用。

Abstract

fter temporary occlusion of left hepatic vein

hepatic arterial embolization （HAE） were performed with 131 I-lipiodol

it can improve the effectiveness of HAE in treatment of hepatocillular carcinoma Using the pig as a model

during the course of embolization of the left hepatic artery with 131I-lipiodol

temporary occlusion of the left hepatic vein was done in the experimental group Lipiodol was labelled with 131I using exchanged reaction method The labelled rate was 95% The lung/liver radioactive ratio

radioactive distribution and the condition of radioactive decay in body was obtained by the SPECT imaging after operation The radioactive ratio of the lung/liver in experimental group was lower than that in control group （<005） on the 1st and 3rd days after operation and has no significant difference on the 5th

7th and 14th days （<005） The effective half-life of 131I-lipiodol was 453 day （median） The pathological change of experimental group was more severe than control group expressing spotty infarct

fibrinoid necrosis

coagulation necrosis etc The result of experiment showed that this method is safe

effective and can tentatively be used clinically

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131I 碘化油在阻断左肝静脉时动脉栓塞的动物实验研究

Experimental study of hepatic arterial embolization with 131I-lipiodol in temporary occlusion of the left hepatic vein

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摘要

Abstract

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references

¹³¹I 碘化油在阻断左肝静脉时动脉栓塞的动物实验研究