? To investigate the relation between GMP-140 with the progress and mechanism of cerebrovascular diseases

the level of GMP-140 in both platelet and plasma in 76 cases of cerebrovascular diseases and 35 normal controls were determined by radioimmunoassay （RIA）. Results showed that the level of GMP-140 in both platelet and plasma of cerebrovascular diseases were remarkably higher than that in normal controls（P<0.001）; significant difference also existed in both platelet and plasma GMP-140 between cerebral hemorrhage

vertebral-basilar artery blood supply insufficiency

and normal controls（P<0.01）; significant difference of the level of both platelet and plasma GMP-140 also occured before and after a three week thrombolytic therapy. Morever

positive correlation was found between platelet and plasma GMP-140 level （0.76

0.49

0.20）; No difference existed in platelet count between cerebrovascular diseases and normal controls（P>0.05）. It was concluded that the progress

develpment

and prognosis of cerebrovascular diseases is strongly related to the platelet function and the level of GMP-140.