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广州医学院
纸质出版日期:1996-05-01
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[1]强永刚,谢岳锐,王家鑫.人体透明质酸代谢中的某些肿瘤学特征探讨[J].核技术,1996(05):301-304.
Study on some oncologic properties of hyaluronic acid metabolism in human body[J]. Nuclear techniques, 1996, (5).
研究了191例人体透明质酸(HA),发现胚胎组织中HA含量为(2038.39±336.51μg/L),新生儿血清HA值为720.81±385.76119/L,随着年龄增大血清HA逐渐下降,大约6月龄后血清HA较稳定地保持在45.92±35.92μg/L水平;肿瘤患者血清HA增高,中枢神经系统肿瘤脑脊液中HA显著增高。由于HA在新生儿中存在着胚胎现象,所以成年肿瘤患者血液或脑脊液中HA增高可能与“癌胚现象”有关。
Human hyaluronic acid(HA) in 191 healthy donors were studied.It was found that serum HA concentration was significantly elevated(2038.39±336.51 μg/L)in fetuses and still at higher level(720.81±385.76μg/L)in neonates. It decreased gradually with aging and maintained a steady state at 45.92±35.92 μg/L 6 months after birth. Patients with neoplasm had increased HA in blood
and an elevated HA value in CSF was noted for patients with malignancy of central nervous system.As fetal tissues contain a large amount of HA
increased HA concentration in patients with neoplastic disease may be regarded as an oncofetal phenomenon.
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