Experimental study on ̄(211)At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice
Experimental study on ̄(211)At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice[J]. Nuclear techniques, 1996, (5).
Experimental study on ̄(211)At labelled monoclonal antibody 3H11 and its Fab fragment radioimmunotherapy for human gastric cancer xenografts in nude mice[J]. Nuclear techniques, 1996, (5).DOI:
Experimental radioimmunotherapy investigation of α-emitting radionuclide.211At labelled anti-gastric cancer monoclonal antibody 3H11 and its Fab fragment for nude mice carrying human gastric cancer xenografts was conducted.Three i.p.injections of 14.8 or 22.2 kBq/g mouse were given
once every 5 days.The results showed that the growth of tumor xenografts was inhibited efficiently.The most evident therapy effect was observed at 15 days after treatment
and the tnmor inhibition rates were 65% and 72%
respectively.No radiation injury of important organs was found.