帕金森病模型大鼠脑多巴胺D<sub>2</sub>受体放射自显影、病理形态学及行为的联合观察

林岩松; 林祥通; 张天谊; 王博诚

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帕金森病模型大鼠脑多巴胺D₂受体放射自显影、病理形态学及行为的联合观察

更新时间：2021-04-09

- 帕金森病模型大鼠脑多巴胺D₂受体放射自显影、病理形态学及行为的联合观察
- Exploration of central dopamine D₂ receptors by autoradiography,pathology and functional behaviour observation in rat model with experimental parkinsonism
- 核技术 1996年第11期
- 作者机构：
  
  1. 上海医科大学附属华山医院
  2. 核医学国家重点实验室
  3. 上海医科大学附属华山医院核医学国家重点实验室
- 作者简介：
- 基金信息：
  
  核医学国家重点实验室青年基金()
- DOI：
  中图分类号： TL65
- 纸质出版日期：1996-11-01
- 稿件说明：
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[1]林岩松,林祥通,张天谊,王博诚.帕金森病模型大鼠脑多巴胺D_2受体放射自显影、病理形态学及行为的联合观察[J].核技术,1996(11):641-645.

Exploration of central dopamine D₂ receptors by autoradiography,pathology and functional behaviour observation in rat model with experimental parkinsonism[J]. Nuclear techniques, 1996, (11).
[1]林岩松,林祥通,张天谊,王博诚.帕金森病模型大鼠脑多巴胺D_2受体放射自显影、病理形态学及行为的联合观察[J].核技术,1996(11):641-645. DOI：

Exploration of central dopamine D₂ receptors by autoradiography,pathology and functional behaviour observation in rat model with experimental parkinsonism[J]. Nuclear techniques, 1996, (11). DOI：

摘要

应用脑立体定位技术，建立稳定、可靠、重复性好、与人类帕金森病的病理及行为学改变相似的偏侧大鼠模型。在此基础上，应用１２５Ⅰ－ＩＢＺＭ对其进行脑内Ｄ２受体分布的放射自显影研究。６只帕金森病大鼠病侧纹状体／额叶皮质放射性计数比值为５．３２±０．３７，较健侧及对照组的比值明显升高（Ｐ＜０．０５），与病理形态改变符合性好、且其增高的数值与阿朴吗啡诱导旋转的转数呈正相关（ｒ＝０．９５６），印证了早期帕金森病时Ｄ２受体的上调效应。１２５Ⅰ－ＩＢＺＭ作为Ｄ２受体配基可以很好地反映脑内Ｄ２受体的分布及变化，为将ＩＢＺＭ用于早期帕金森病的临床影像诊断提供理论依据。

Abstract

The rat model with experimental parkinsonism mimic the course of human parkinsonism were made by cerebral-stereotaxic techniques. 125I-IBZM was used to evaluate the D2 receptors distribution by autoradiographic analysis of coronal brain section. In 6 parkinsonism model rats

on the lesioned side the striatum/frontal cortex ratio was 5.32 ± 0.37

it was significantly（P<0.05） higher than the contralateral intact side and the control group

and coincided with the pathological findings and neurological changes. Also

there was a positive correlation between the increased value and numbers of apomorphine induced rotation. All of the above verified that there was an up regulation effect in early parkinsonism

and 125I-IBZM as the ligand of D2 receptor

can well reflect the distribution and changes of D2 receptors

and also as the theoretical basis for the clinical imaging diagnosis.

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帕金森病模型大鼠脑多巴胺D2受体放射自显影、病理形态学及行为的联合观察

Exploration of central dopamine D2 receptors by autoradiography,pathology and functional behaviour observation in rat model with experimental parkinsonism

DOI：

摘要

Abstract

关键词

Keywords

references

帕金森病模型大鼠脑多巴胺D₂受体放射自显影、病理形态学及行为的联合观察

Exploration of central dopamine D₂ receptors by autoradiography,pathology and functional behaviour observation in rat model with experimental parkinsonism