The dynamic change of endothelial cell,endothelin and 6-K-PGF1a in circulating blood of the patients with coronary heart disease[J]. Nuclear techniques, 1995, (11).
The dynamic change of endothelial cell,endothelin and 6-K-PGF1a in circulating blood of the patients with coronary heart disease[J]. Nuclear techniques, 1995, (11).DOI:
With the circulating endothelial cell(CEC)as an indicator of vessel endothelial cell(VEC)injury
and plasma endothelin(ET)and prostaglandin F1a(PGI2)reflecting the functional change of the VEC
a comparative study between 85 patients with coronary heart disease and 30 normal health
and also a dynamic observation of 50 patients with unstable angina pectoris and 20 patients with acute myocardial infarction(AMI)were reported. The result showed that in patients with coronary heart disease
peripheral blood circulating CEC and ET level was increased(P<0.001)
while the PGI2 decreased (P<0.01)
all these were more significant in patients with unstable angina pectoris and myocardial infarction
and its magnitudecorrelated closely with the seventy of the disease. All these showed that the VEC injury and the imbalance of its endothelial relaxing and contracting factors have played an important role in the pathogenesis of coronary heart disease.