The rat model with regional cerebrovascular ischemia
mimic the course of human cerebral thrombosis and simulating the 99mTc-HM-PAO distribution of ischemic apoplexy
were used in this study. After the occlusion of middle cerebral artery(MCAo)
the activity ratio of lesion to normal side was 0.77±0.24(n= 11)
which showed significant difference with control group(p<0.05)
and also coincided with the pathological findings and neurological changes.All of this verified that the distribution of 99mTc-HM-PAO was well correlated with the brain blood perfusion.