mTc-DTPA renography was performed in 64 cases of type Ⅱ diabetes mellitus and 20 control subjects. The value of GFR in the controls was 113±11.7ml/min. The value of GFR in 15 of 43 patients with negative proteinuria was more than 140ml/min
but GFR in the 21 diabetes with positive proteinuria was 76 ± 32.9ml/min.These data indicated that 99mTc-DTPA renography is a accurate and sensitive method for evaluation of hyperfiltration in early diabetes mellitus.