Mouse experiment revealed that the concentration of 99mTc-EC in kidney was highly dependent on the chemical amount of the injected tracer.A highest concentration in kideney was found at a dose of 1.25 mg per kg of body weight
with a kidney/liver ration as high as 3.2.Its toxicity was low and only a small percentage was bound to plasma protein. Preliminary study on 14 healthy volunteers suggests that 99mTc- EC is a hopeful functional imaging agent for kidney.