调理心肾中药对拟痴呆大鼠脑组织中M和GABA受体功能的影响

莫启忠; 宫斌; 陈坤华; 方军; 李伟雄; 王菊美; 匡兴伟; 陈荣

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调理心肾中药对拟痴呆大鼠脑组织中M和GABA受体功能的影响

更新时间：2021-04-09

- 调理心肾中药对拟痴呆大鼠脑组织中M和GABA受体功能的影响
- The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid （GABA） receptor in brain tissues of analogue dementia rats
- 核技术 1993年第5期
- 作者机构：
  
  1. 上海中医学院
  2. 深圳市中医医院
  3. 上海中医学院,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：1993-05-01
- 稿件说明：
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[1]莫启忠,宫斌,陈坤华,方军,李伟雄,王菊美,匡兴伟,陈荣.调理心肾中药对拟痴呆大鼠脑组织中M和GABA受体功能的影响[J].核技术,1993(05):295-298.

Mo Qizhong Gong Bin Fang Jun Chen Kunhua Li Weixiong Wang JumeiKuang Xingwei Chen Rong. The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid （GABA） receptor in brain tissues of analogue dementia rats[J]. Nuclear techniques, 1993, (5): 295-298.
[1]莫启忠,宫斌,陈坤华,方军,李伟雄,王菊美,匡兴伟,陈荣.调理心肾中药对拟痴呆大鼠脑组织中M和GABA受体功能的影响[J].核技术,1993(05):295-298. DOI：

Mo Qizhong Gong Bin Fang Jun Chen Kunhua Li Weixiong Wang JumeiKuang Xingwei Chen Rong. The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of cholinergic M- and Gamma ammo- butyric acid （GABA） receptor in brain tissues of analogue dementia rats[J]. Nuclear techniques, 1993, (5): 295-298. DOI：

摘要

以

H-QNB和

H-GABA为放射性配基

用受体放射性配基结合分析法

测出拟痴呆模型大鼠大脑皮层和海马组织中的M受体和小脑组织中的GABA受体的R

值明显降低;M受体的K

值在大脑皮层中明显减少

在海马中略有升高。小脑中GABA受体的K

值显著降低。调理心肾中药及喜德镇（Hydergin

为国外常用抗老年痴呆药）能使降低的M受体和GABA受体的R

值均明显升高

接近正常水平。对K

值则有不同程度的调整作用。

Abstract

3H- QNB and 3H- GABA were used as radioactive ligand for M- and GABA receptors respectively. M- and GABA receptors were assayed by radioligand binding assay （RBA） in cerebral cortex

hippocampus and cerebellum of analogue dementia rats. It was found that Rt of M receptor was decreased in cerebral cortex and hippocampus and Rt of GABA receptor was decreased in cerebellum of analogue dementia rats. The dissociation constant （KD） of M- receptor was decreased significantly in cerebral cortex and KD value of GABA receptor was decreased in cerebellum of analogue dementia rats. The decreased Rt of M- and GABA receptor in brain tissue of analogue dementia rats was raised by Heart- and Kidney-Benefiting Chinese Herbs as well as hydergin.

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