<sup>99m</sup>Tc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验

罗世能; 谢敏浩; 奚月芬; 冯瑛瑛; 国毓智

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^99mTc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验

更新时间：2021-04-09

- ^99mTc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验
- The preparation and biodistribution of ^99mTc-cyclohexanedione dioxime and its methaneboronic acid adduct
- 核技术 1993年第11期
- 作者机构：
  
  1. 江苏省原子医学研究所
  2. 江苏省原子医学研究所,无锡,214063
- 作者简介：
- 基金信息：
  
  核医学国家重点实验室和江苏省卫生厅科研项目()
- DOI：
  中图分类号：
- 纸质出版日期：1993-11-01
- 稿件说明：
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[1]罗世能,谢敏浩,奚月芬,冯瑛瑛,国毓智.~(99m)Tc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验[J].核技术,1993(11):687-689.

Luo Shineng Xie Minhao Xi Yuefen Feng Yingying Guo Yuzhi. The preparation and biodistribution of ^99mTc-cyclohexanedione dioxime and its methaneboronic acid adduct[J]. Nuclear techniques, 1993, (11): 687-689.
[1]罗世能,谢敏浩,奚月芬,冯瑛瑛,国毓智.~(99m)Tc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验[J].核技术,1993(11):687-689. DOI：

Luo Shineng Xie Minhao Xi Yuefen Feng Yingying Guo Yuzhi. The preparation and biodistribution of ^99mTc-cyclohexanedione dioxime and its methaneboronic acid adduct[J]. Nuclear techniques, 1993, (11): 687-689. DOI：

摘要

实验结果表明

99m

Tc-CDO的标记率受体系的pH值影响较小

而

99m

Tc-CDO-MeB只有在pH=3.5—4.0时标记率才能大于90％。小鼠体内分布实验表明

99m

Tc-CDO-MeB在动物心肌中有较高的吸收

但随时间延长而迅速清除。心/肝比值在给药后1、5和10min时分别为3、1.5和0.8。

99m

Tc-CDO在心、脑中的浓聚明显低于

99m

Tc-CDO-MeB。

Abstract

This paper reports the preparation and biodistribution of 99mTc-cyclo-hexanedione dioxime （99mTc-CDO） and its methaneboronic acid adduct （99mTc-CDO-MeB）. The result showed that pH value exerts greater effect on the labelling yield of 99mTc- CDO- MeB than that of 99mTc- CDO. When pH value was 3.5-4.0

the labelling yield of 99mTc-CDO-MeB was higher than 90%. Biodistribution experiment showed that 99mTc-CDO-MeB was taken by heart and brain in the first few minutes after intravenous injection. The uptakes of 99mTc-CDO-MeB by heart and brain were higher than those of 99mTc- CDO.

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99mTc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验

The preparation and biodistribution of 99mTc-cyclohexanedione dioxime and its methaneboronic acid adduct

DOI：

摘要

Abstract

关键词

Keywords

references

^99mTc标记环己二酮二肟及其甲基硼酸加成物和初步动物实验

The preparation and biodistribution of ^99mTc-cyclohexanedione dioxime and its methaneboronic acid adduct