肝癌栓塞治疗剂<sup>131</sup>I-碘化油的制备和动物实验

胡国瑛; 王自法

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肝癌栓塞治疗剂¹³¹I-碘化油的制备和动物实验

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- 肝癌栓塞治疗剂¹³¹I-碘化油的制备和动物实验
- Embolistic therapy agent of liver cancer: preparation of ¹31I - lipiodol and its animal experiment
- 核技术 1992年第11期
- 作者机构：
  
  1. 西安医科大学第一附属医院
  2. 西安医科大学第二附属医院,西安,710061
  3. ,西安,710004
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：1992-11-01
- 稿件说明：
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[1]胡国瑛,王自法.肝癌栓塞治疗剂~(131)I-碘化油的制备和动物实验[J].核技术,1992(11):661-664.

Hu Guoying. Embolistic therapy agent of liver cancer: preparation of ¹31I - lipiodol and its animal experiment[J]. Nuclear techniques, 1992, (11): 661-664.
[1]胡国瑛,王自法.肝癌栓塞治疗剂~(131)I-碘化油的制备和动物实验[J].核技术,1992(11):661-664. DOI：

Hu Guoying. Embolistic therapy agent of liver cancer: preparation of ¹31I - lipiodol and its animal experiment[J]. Nuclear techniques, 1992, (11): 661-664. DOI：

摘要

以丙酮为溶剂进行同位素交换反应制备

131

I-碘化油

操作简便

标记率可达95％以上。室温放置15d及高压灭菌后未见脱碘现象。γ照相显示

131

I-碘化油注入狗的肝动脉后

仅选择性地蓄积于注入动脉的供血区内

甲状腺及肺等其它部位未见核素蓄积。

131

I-碘化油在肝内的有效半衰期为4.92±0.66d。每毫升血液放射性仅为注入量的0.09±0.04％

提示

131

I-碘化油性能稳定

适宜临床应用。

Abstract

Lipiodol was labelled with 131I using an iodine exchange reaction with acetone as solvent. The labelling rate was 95%. No dehalogenation was detected within 15 days at room temperature or after sterilization. Animal experiments showed that after hepatic arterial injection 131I -lipiodol was selectively accumulated in the embolized local area. No increased activity was observed in the thyroid

lung or other areas. The effective half - life in liver was 4. 92±0. 66 days. The blood radioactivity per ml was 0. 09±0. 04% of the injected dose . The results suggest that the 131I - lipiodol is very stable and suitable for clinical application.

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肝癌栓塞治疗剂131I-碘化油的制备和动物实验

Embolistic therapy agent of liver cancer: preparation of 131I - lipiodol and its animal experiment

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摘要

Abstract

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references

肝癌栓塞治疗剂¹³¹I-碘化油的制备和动物实验

Embolistic therapy agent of liver cancer: preparation of ¹31I - lipiodol and its animal experiment