用PIXE分析法研究抗坏血酸钛染毒后大鼠体内的钛和其它元素的浓度变化

刘年庆; 张晓峰; 焉伶娜; 冯松林; 钟溟; 纪云晶; 王敏; 栗建林; 金枫

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用PIXE分析法研究抗坏血酸钛染毒后大鼠体内的钛和其它元素的浓度变化

更新时间：2021-04-09

- 用PIXE分析法研究抗坏血酸钛染毒后大鼠体内的钛和其它元素的浓度变化
- Variations of concentration of titanium and other elements in Wister rats after titanium-ascorbate administration
- 核技术 1992年第4期
- 作者机构：
  
  1. 中国科学院高能物理研究所
  2. 北京市劳动卫生职业病防治研究所,北京,100081
  3. ,北京
- 作者简介：
- 基金信息：
  
  国家自然科学基金(11605241;11875290;11975276)
- DOI：
  中图分类号：
- 纸质出版日期：1992-04-01
- 稿件说明：
移动端阅览
[1]刘年庆,张晓峰,焉伶娜,冯松林,钟溟,纪云晶,王敏,栗建林,金枫.用PIXE分析法研究抗坏血酸钛染毒后大鼠体内的钛和其它元素的浓度变化[J].核技术,1992(04):251-256.

Liu Nianqing Zhang Xiaofeng Yan Lingna Feng Songlin Zhong Ming. Variations of concentration of titanium and other elements in Wister rats after titanium-ascorbate administration[J]. Nuclear techniques, 1992, (4): 251-256.
[1]刘年庆,张晓峰,焉伶娜,冯松林,钟溟,纪云晶,王敏,栗建林,金枫.用PIXE分析法研究抗坏血酸钛染毒后大鼠体内的钛和其它元素的浓度变化[J].核技术,1992(04):251-256. DOI：

Liu Nianqing Zhang Xiaofeng Yan Lingna Feng Songlin Zhong Ming. Variations of concentration of titanium and other elements in Wister rats after titanium-ascorbate administration[J]. Nuclear techniques, 1992, (4): 251-256. DOI：

摘要

用PIXE分析法测定了在抗坏血酸钛静脉注射和灌胃染毒后大鼠血液中Ti的含量随时间的变化及对其它生命元素（Ca、P、K、Fe、Cu和Zn）的影响。用抗坏血酸钛50 mg/kg体重单次静脉注射染毒后

在血液中的动力学模型为三室开放模型。用500mg/kg剂量单次灌胃染毒0.5—1.5h后

Ti在血液中的浓度达到最高值。测量的结果还表明

染毒后血钙的浓度明显升高

钾的浓度降低显著

铁元素浓度有下降趋势

铜和锌的浓度下降不明显

但本身变化起伏较大。可以认为抗坏血酸钛对动物的增重作用是由于它能促进机体对钙的吸收。

Abstract

The concentrations of Ti and .Ca

and Zn in blood samples were determined by PIXE after a single intravenous and a single oral dosing with titanium-ascorbate （Ti-Vc） in Wister rats. Following the intravenous injection with 50 mg Ti-Vc/kg of body weight the absorption

distribution and clearance in blood could be described by an exponential equation with three terms. After being gavaged with 500 mg Ti-Vc/kg of body weight

the content of Ti reached the highest level in 1.5h. The concentration of Ca was increasing with the absorption

distribution and clearance of Ti in blood

while the contents of Fe and K were decreasing. And the contents of Cu and Zn were significantly fluctuating. The effect of Ti on animal growth might be explained by the fact that Ti-Vc supplementation could promote the absorption of Ca.

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