To discuss the applicability of 99TCm-TRODAT-1 SPECT imaging of dopamine transporter in monitoring the state of Parkinson’s disease (PD)

20 patients with PD and a control group of 14 healthy subjects were chosen to conduct dopamine transporter (DAT) imaging by SPECT with 99TCm-TRODAT-1. The radioactive ratio between bilateral striatum and cerebellum and the asymmetry index (AI) of bilateral striatum were computed by using the region of interest (ROI) technology. Meanwhile

the PD patients were classified by the improved Hoehn-Yahr Disability Score and then evaluated by Unified Parkinson’s Disease Rating Scale (UPDRS). The findings show that there is a negative correlation between the bilateral ST/CB mean of the PD and the Hoehn-Yahr grading of the patients’ state of illness

the UPDRS score

the patients’ self-caring ability

the ability to move around. As for the asymmetry index AIPD

there was a positive correlation with the duration of disease

and a significant difference between the PD and the control group

with the former much higher than the latter. Therefore

the dopamine transporter imaging by SPECT with 99TCm-TRODAT-1 can monitor the state of Parkinson’s disease

and show the symptom severity of Parkinson’s disease.