The ligand of N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4’-iodo phenyl)nortropane (FP-β-CIT) and its tributylstannyl precursor were synthesized by hydrolysis of cocaine

and then dehydration

esterification

Grignard reaction

n-demethylation

iodination

n-alkylation and tributylstannylation. 125/131 I-FP-β-CIT were prepared by oxidation radioiododestannylation

using peroxyacetic acid as oxidant

of its tributylstannyl precursor. The stable labeled compound was synthesized with high radiochemical purity at pH 4-7.