18F-Fluoroethylcholine(18F-FeCH)

a 18F-labeled choline derivatives

is a very sensitive molecular imaging agent for diagnosis of prostate cancer and other types of cancers

indicating a promising future for clinic applications.In this study

automatic synthesis of 18F-FeCH was developed using a "two-step one-pot" method modified from Explora FDG4 synthesis module that are commercially available.The first step is the nucleophilic displacement reaction of 18F-fluoride and 1

2-bis(tosyloxy)ethane at 90°C for 5 min to form labeled intermediate 18F-fluoroethyltosylate.The second step is to form alkylation between 18F-fluoroethyltosylate and N

N-dimethyl-2-hydroxyethylammonium at 100°C for 8 min.The target product of 18F-FeCH was obtained via Sep-pak cartridge separation with about 30% of radiochemical yields(no decay corrected) and more than 99% of radiochemical purity within 65 min of total synthesis time.