JI Shundong1 FANG Wei3 ZHOU Jundong2 HE Zuoxiang3 LIU Xiujie3 RUAN Changgeng1 ZHAO Ming4 1. Preparation and biodistribution of new apoptosis imaging regent 99mTc-FM-2[J]. Nuclear techniques, 2007, (8): 679-682.
JI Shundong1 FANG Wei3 ZHOU Jundong2 HE Zuoxiang3 LIU Xiujie3 RUAN Changgeng1 ZHAO Ming4 1. Preparation and biodistribution of new apoptosis imaging regent 99mTc-FM-2[J]. Nuclear techniques, 2007, (8): 679-682.DOI:
FM-2 was modified with 2-iminotholane and labeled with 99Tcm-GH. The radiochemical purity of 99mTc-FM-2 was over 95% and can stable in the routine temperature for more than 8 hours. Biodistribution in mice showed 99mTc-FM-2 was cleared mainly by liver and kidney. The normal myocardial showed a high uptake and rapid clearance of 99mTc-FM-2.