<sup>188</sup>Re对血管平滑肌与内皮细胞的辐射差异性

黄钢; 任晓庆; 陈建伟; 毛家亮; 黄定九

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¹⁸⁸Re对血管平滑肌与内皮细胞的辐射差异性

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- ¹⁸⁸Re对血管平滑肌与内皮细胞的辐射差异性
- The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells
- 核技术 2002年第11期
- 作者机构：
  
  1. 上海第二医科大学附属仁济医院核医学科
  2. 上海第二医科大学附属仁济医院核医学科,上海,200001
- 作者简介：
- 基金信息：
  
  (No.ZX069);(No.ZX069)
- DOI：
  中图分类号： R817.5
- 纸质出版日期：2002-11-01
- 稿件说明：
移动端阅览
[1]黄钢,任晓庆,陈建伟,毛家亮,黄定九.~(188)Re对血管平滑肌与内皮细胞的辐射差异性[J].核技术,2002(11):901-906.

HUANG Gang REN Xiaoqing CHEN Jianwei MAO Jialiang HUANG Dingju 1. The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells[J]. Nuclear techniques, 2002, (11): 901-906.
[1]黄钢,任晓庆,陈建伟,毛家亮,黄定九.~(188)Re对血管平滑肌与内皮细胞的辐射差异性[J].核技术,2002(11):901-906. DOI：

HUANG Gang REN Xiaoqing CHEN Jianwei MAO Jialiang HUANG Dingju 1. The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells[J]. Nuclear techniques, 2002, (11): 901-906. DOI：

摘要

为比较 β射线对平滑肌和内皮细胞的增殖抑制作用

探寻血管内放射治疗中保护内皮细胞的措施

应用放射性核素188Reβ射线对培养的平滑肌细胞和内皮细胞进行了辐射。通过细胞增殖计数、细胞增殖周期分析和3 H -TdR掺入实验观察

研究辐射对平滑肌和内皮细胞在增殖方面的影响。结果显示

5 .2Gy剂量 β辐射

平滑肌细胞增殖计数、细胞增殖率、3 H -TdR掺入率显著下降

而内皮细胞的上述指标则无明显改变 ;高于 10Gy

小于 2 0Gy的剂量辐射

两组细胞的增殖均受到明显抑制。表明在体外细胞培养条件下

平滑肌细胞及内皮细胞对高剂量 β辐射的敏感性一致

而对低剂量 β辐射

内皮细胞较平滑肌细胞耐受。 5 .2Gy低剂量 β辐射

是一个既能有效抑制平滑肌细胞增殖

又不影响内皮细胞增殖

且对心肌细胞无损伤作用的血管内放疗窗口。

Abstract

To compare the effects of β-particle radiation on proliferation of smooth muscle cells and endothelial cells

and to explore the methods for protecting endothelial cells during endovascular radiotherapy

the smooth muscle cells and endothelial cells cultured in vitro were irradiated by 188Re with different single doses. By means of proliferation cell count

cell cycle progression analysis

3H-TdR incorperation

the effects of β-particle on proliferation of smooth muscle cells (SMCs) and endothelial cells (ECs) were studied and compared. SMCs proliferation

but not ECs

was significantly inhibited by β-particle irradiation with dose of 5.2Gy. SMCs and ECs were inhibited similarly by β-particle irradiation with doses >10.3Gy and <20Gy. ECs appeared to be more radioresistant than SMCs at a lower dose. A safety window of treatment with 188Re at a dose of 5.2Gy was found between the smooth muscle cells and endothelial cells cultured in vitro.

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188Re对血管平滑肌与内皮细胞的辐射差异性

The difference of188Re radiation on proliferation of smooth muscle cells and endothelial cells

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摘要

Abstract

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¹⁸⁸Re对血管平滑肌与内皮细胞的辐射差异性

The difference of¹⁸⁸Re radiation on proliferation of smooth muscle cells and endothelial cells