Through the comparative study of biodistribution of monoclonal antigranulocyte antibody and HIG in inflammatory model rats

the difference of biodistribution of these two kinds of agents in inflammatory model rats were compared. The results showed that both McAb and HIG had much accumulation in liver

spleen and marrow. The accumulation in McAb group was higher than that in HIG group

the difference between the two groups was statistically significant ( P <0.01); McAb group showed lower radioactivity than HIG group in lung

stomach

intestine and muscle; McAb group has significant lower radioactivity than HIG group in blood and the radioactivity in blood disappeared rapidly in McAb group; the kidney accumulated very much radioactivity in two groups. The difference of the ratio of %ID between inflammatory limb (target) and contralateral healthy limb (no target) (T/NT) was insignificant in two groups at six and nine hours after injection of antibody

but McAb group owned higher T/NT ratio than HIG group at twenty-four hours

the difference has statistical significance ( P <0.05). The McAb was able to image the inflammatory sites in inflammatory limb

but the superiority of McAb was less obvious than HIG at early stage. McAb is more suitable to image the inflammatory sites in lung

stomach

intestine and muscle than HIG.