The [11C]methyl iodide (11C-CH3I ) is a very important methylated precursor in 11C labeled PET tracer synthesis. In order to get higher and more stable radiosynthesis yield of 11C-CH3I

this research aims at optimizing the key steps over the radiosynthesis procedure. After the system temperature of the module was optimized

a higher synthesis yield of 11C-CH3I (90.2 ±2.5)% was got

and 100% success rate of the synthesis was obtained at the same time. The synthesis time was 11min

and the radiochemical purity of the precursor was over 98%. Thus optimization of the system can lead to producing 11C-CH3I with higher and more stable yield.