This paper describes the preparation of N

N’-diethyl-6-chloro-(4’-iodophenyl)-imidazo-[1

2-a] pyridine-3-acetamide (CLINDE) and [131I]- labelled ([131I]- CLINDE). Non-radioactive imidazo[1

2-a]pyridine was synthesized by condensation of 5-chloro-2-aminopyridines with the bromo keto amides. Radiolabelling [131I]- imidazo [1

2-a]pyridines was prepared by iododestannylation with Na[131I] in the presence of peroxide of hydrogen and purified by C18 reverse phase HPLC. Non-radioactive imidazo-[1

2-a] pyridine was synthesized at a total yield of 30.8%. Radiolabelling [131I]-imidazo [1

2-a]pyridines was prepared with a radiochemical yield of 80% and a radiochemical purity of greater than 98%. An improved

economical process is suited for preparing N

N’-diethyl-6-chloro-(4’-iodo-phenyl)-imidazo-[1

2-a]pyridine-3-acetamide and its radiosynthesis.