<sup>18</sup>F-FDG符合显像诊断梗死心肌活力的实验研究

许长德; 陈绍亮; 姚瑞敏; 张庆勇; 石洪成

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¹⁸F-FDG符合显像诊断梗死心肌活力的实验研究

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- ¹⁸F-FDG符合显像诊断梗死心肌活力的实验研究
- ¹⁸F-FDG coincidence imaging diagnosis of viability of infarction myocardium
- 核技术 2006年第5期
- 作者机构：
  
  1. 复旦大学附属中山医院核医学科
  2. 复旦大学附属中山医院核医学科,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R817.4
- 纸质出版日期：2006-05-01
- 稿件说明：
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[1]许长德,陈绍亮,姚瑞敏,张庆勇,石洪成.~(18)F-FDG符合显像诊断梗死心肌活力的实验研究[J].核技术,2006(05):372-375.

XU Changde CHEN Shaoliang YAO Ruimin ZHANG Qingyong SHI Hongcheng. ¹⁸F-FDG coincidence imaging diagnosis of viability of infarction myocardium[J]. Nuclear techniques, 2006, (5): 372-375.
[1]许长德,陈绍亮,姚瑞敏,张庆勇,石洪成.~(18)F-FDG符合显像诊断梗死心肌活力的实验研究[J].核技术,2006(05):372-375. DOI：

XU Changde CHEN Shaoliang YAO Ruimin ZHANG Qingyong SHI Hongcheng. ¹⁸F-FDG coincidence imaging diagnosis of viability of infarction myocardium[J]. Nuclear techniques, 2006, (5): 372-375. DOI：

摘要

将6只20kg的小型猪制作心肌梗死模型

进行心肌99Tcm-甲氧基异丁基异腈（99Tcm-sestamibi

99Tcm-MIBI）血流灌注显像确定梗死区

用18F-脱氧葡萄糖（18F-fluorodeoxyglucose

18F-FDG）观察空腹与糖负荷图像的差别

确定心肌坏死或存活区。制作模型前进行自身对照形成对照组。并进行B超心功能检查。结果显示:心肌梗死区大部分心肌没有活力

99Tcm-MIBI和18F-FDG都没有摄取。空腹时有部分心肌显影

糖负荷时该区域显影程度减轻。

Abstract

The objective of the work is to observe the role of 99Tcm-sestamibi perfusion imaging and coincidence imaging with 18F-FDG for detecting viability of infarct myocardum in miniswine model. Six minipigs with circum- flex branch ligation for the myocardial infarction underwent excising and resting myocardial perfusion imaging with 99Tcm-MIBI by using single photon emission computed tomography (SPECT) and fast and glucose-injection coinci- dence imaging with 18F-FDG. They also underwent the imaging before operation as a normal control group. The re- gion of myocardial infarction of the model was found no uptake of the 99Tcm-MIBI and 18F-FDG. Part myocardium can be imaged in fast state

and after injecting 18F-FDG the images in this region get fainter. It is concluded that the coincidence imaging with 18F-FDG is better to diagnose the viability of infarct myocardium

and fast and glucose stress can display viability of severe ischmia myocardium.

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18F-FDG符合显像诊断梗死心肌活力的实验研究

18F-FDG coincidence imaging diagnosis of viability of infarction myocardium

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¹⁸F-FDG符合显像诊断梗死心肌活力的实验研究

¹⁸F-FDG coincidence imaging diagnosis of viability of infarction myocardium