The specificity of action of angiostatin on vascular endothelial cell is studied. 99Tcm-angiostatin was prepared by the SnCl2 reduced approach

then injected into the mice bearing S180 tumor or Matrigel via tail vein. The whole body distribution and the effect of 99Tcm-angiostatin in vivo were observed on the model of mice bearing S180 tumor and Matrigel by imaging and radioautography. The resultes indicate that the metabolism of 99Tcm-angiostatin is realized mainly by the liver and kidney pathway

and both S180 tumor and Matrigel can specifically uptake 99Tcm-angiostatin. The angiostatin’s role of inhibiting tumor is found on the basis of targeting novel vascular endothelial cell.