中能碳离子束对不同贯穿深度上黑色素瘤B16细胞的辐照存活效应

李强; 周光明; 王菊芳; 李文建; 温小琼; 党秉荣; 颉红梅; 卫增泉

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中能碳离子束对不同贯穿深度上黑色素瘤B16细胞的辐照存活效应

更新时间：2021-03-12

- 中能碳离子束对不同贯穿深度上黑色素瘤B16细胞的辐照存活效应
- Irradiated survival effect of melanoma B16 cells at different penetration depths of intermediate energy heavy-ion beams
- 核技术 2001年第4期
- 作者机构：
  
  1. 中国科学院近代物理研究所,兰州,730000
  2. 中
- 作者简介：
- 基金信息：
  
  (No.ZX069)
- DOI：
  中图分类号： R739.5
- 纸质出版日期：2001-04-01
- 稿件说明：
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[1]李强,周光明,王菊芳,李文建,温小琼,党秉荣,颉红梅,卫增泉.中能碳离子束对不同贯穿深度上黑色素瘤B16细胞的辐照存活效应[J].核技术,2001(04):277-282.

LI Qiang ZHOU Guangming WANG Jufang LI Wenjian WEN Xiaoqiong DANG Bingrong XIE Hongmei WEI Zengquan. Irradiated survival effect of melanoma B16 cells at different penetration depths of intermediate energy heavy-ion beams[J]. Nuclear techniques, 2001, (4): 277-282.
[1]李强,周光明,王菊芳,李文建,温小琼,党秉荣,颉红梅,卫增泉.中能碳离子束对不同贯穿深度上黑色素瘤B16细胞的辐照存活效应[J].核技术,2001(04):277-282. DOI：

LI Qiang ZHOU Guangming WANG Jufang LI Wenjian WEN Xiaoqiong DANG Bingrong XIE Hongmei WEI Zengquan. Irradiated survival effect of melanoma B16 cells at different penetration depths of intermediate energy heavy-ion beams[J]. Nuclear techniques, 2001, (4): 277-282. DOI：

摘要

测量了 4 9.30MeV u及经脊形过滤器展宽的Bragg峰的 74 .55MeV u12 C离子束在不同贯穿深度上辐射后黑色素瘤B16细胞的存活率。结果显示

以存活为终点的B16细胞生物学效应与碳离子束能量沉积同步增大

即Bragg或展宽的Bragg峰区内细胞存活率远低于离子束入射或出射通道处的细胞存活率。通过实验测量与剂量平均LET结合的线性平方模型理论计算存活曲线的比较

发现在实验测量误差范围内两者符合较好。提示 :剂量平均LET结合线性平方模型可能是预测中能重离子束贯穿深度上B16细胞存活效应的一种有效的方法

Abstract

Survival fractions of melanoma B16 cells at different penetration depths exposed to 49.30MeV/u 12 C ion beam and modulated 74.55MeV/u 12 C ion beam with a ridge filter to form a spread-out Bragg peak (SOBP) were measured. The results show the survival response of B16 cells as the biological endpoint to heavy ions increases synchronously with the deposited energy along the beam traversal

that is

the survival fraction near or at the Bragg peak or SOBP is far lower than that at the beam’s entrance or exit channel. Comparisons of the experimental data with calculated survival fractions at different depths predicted by the linear-quadratic survival model combined with dose-averaged LET display a good agreement within the experimental errors. It is prompted that the linear-quadratic model combined with dose-averaged LET possibly is a valid way to calculate the survival effect of B16 cells along the beam penetration under the exposure of the intermediate energy heavy-ion beam.

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