<sup>125</sup>IUdR对人脑胶质瘤细胞SHG44的杀伤作用

李金泉; 鲍耀东; 周岱; 吴翼伟; 江一民; 王博诚; 金坚

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¹²⁵IUdR对人脑胶质瘤细胞SHG44的杀伤作用

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- ¹²⁵IUdR对人脑胶质瘤细胞SHG44的杀伤作用
- Experimental study of the killing effect on human brain glioma SHG44 cells by ¹²⁵IUdR
- 核技术 2001年第11期
- 作者机构：
  
  1. 苏州大学附属第一医院
  2. 核医学国家重点实验室
  4. ,无锡,214063
- 作者简介：
- 基金信息：
  
  核医学国家重点实验室开放科研基金资助()
- DOI：
  中图分类号： R739.4
- 纸质出版日期：2001-11-01
- 稿件说明：
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[1]李金泉,鲍耀东,周岱,吴翼伟,江一民,王博诚,金坚.~(125)IUdR对人脑胶质瘤细胞SHG44的杀伤作用[J].核技术,2001(11):881-884.

LI Jinquan BAO Yaodong ZHOU Dai WU Yiwei JIANG Yimin. Experimental study of the killing effect on human brain glioma SHG44 cells by ¹²⁵IUdR[J]. Nuclear techniques, 2001, (11): 881-884.
[1]李金泉,鲍耀东,周岱,吴翼伟,江一民,王博诚,金坚.~(125)IUdR对人脑胶质瘤细胞SHG44的杀伤作用[J].核技术,2001(11):881-884. DOI：

LI Jinquan BAO Yaodong ZHOU Dai WU Yiwei JIANG Yimin. Experimental study of the killing effect on human brain glioma SHG44 cells by ¹²⁵IUdR[J]. Nuclear techniques, 2001, (11): 881-884. DOI：

摘要

为评价12 5IUdR对人脑胶质瘤细胞SHG4 4的杀伤作用

把12 5IUdR加入到SHG4 4细胞的培养基中

孵育后测量细胞摄取12 5IUdR的放射性活度 ;采用克隆形成法测定12 5IUdR对SHG4 4细胞生长抑制的效果。结果表明

培养基中12 5IUdR浓度增加时

SHG4 4细胞对12 5IUdR的摄取量也相应增加（相关系数r =0 .9917）。SHG4 4细胞摄取12 5IUdR后生长受到明显抑制

细胞存活分数与培养基中12 5IUdR浓度呈直线负相关（r =- 0 .9736 ）

其半数致死剂量LD50 为（8.7± 0 .12 ）kBq/mL

12 5IUdR组的SHG4 4细胞存活分数明显低于Na12 5I组（P <0 .0 0 1）。结果提示

12 5IUdR能够掺入到SHG4 4细胞中

12 5IUdR对SHG4 4细胞有明显的杀伤作用

说明12 5IUdR可望成为治疗脑胶质瘤的潜在的一种放射性药物。

Abstract

To evaluate the cytocidal effect of 125 IUdR in human glioma cell line SHG44

125 IUdR were added to the RPMI1640 culturing medium. The amount of 125 IUdR uptake by SHG44 cells was evaluated through measuring the radioactivity per cell; the killing effects of 125 IUdR on SHG44 cells were estimated by colony forming method. The amounts of 125 IUdR uptake by SHG44 were growing up as a function of 125 IUdR dose in the medium ( r =0.9917). The surviving fraction was correlated with the concentration of 125 IUdR ( r =-0.9736). The LD 50 of 125 IUdR group was (8.7±0.12)kBq/mL and the surviving fraction of 125 IUdR group was significantly lower than that of Na 125 I group ( P <0.001). 125 IUdR can be incorporated into the SHG44 cells

and the concentration of 125 IUdR in SHG44 cells was influenced by 125 IUdR dose in the medium. The inhibitive effects of 125 IUdR on SHG44 cells were obviously.

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125IUdR对人脑胶质瘤细胞SHG44的杀伤作用

Experimental study of the killing effect on human brain glioma SHG44 cells by 125IUdR

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摘要

Abstract

关键词

Keywords

references

¹²⁵IUdR对人脑胶质瘤细胞SHG44的杀伤作用

Experimental study of the killing effect on human brain glioma SHG44 cells by ¹²⁵IUdR