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1. 苏州大学附属第一医院
2. 苏州大学附属第一医院,苏州,215006
纸质出版日期:2001-11-01
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[1]苏成海,毕佩英,江一民,吴翼伟,张玮,董慎安,桑士标,陈卫昌,徐峰坡,吴星红.~(99m)Tc-MIBI测定门静脉压力分析肝硬化病情及评价疗效[J].核技术,2001(11):911-914.
SU Chenghai BI Peiying JIANG Yimin WU Yiwei ZHANG Wei DONG Shen’an SANG Shibiao CHEN Weichang XU Fengpo WU Xinghong. Measurement of portal vein pressure by 99mTc-MIBI for the evaluation of the staging and therapeutic effect in cirrhosis[J]. Nuclear techniques, 2001, (11): 911-914.
[1]苏成海,毕佩英,江一民,吴翼伟,张玮,董慎安,桑士标,陈卫昌,徐峰坡,吴星红.~(99m)Tc-MIBI测定门静脉压力分析肝硬化病情及评价疗效[J].核技术,2001(11):911-914. DOI:
SU Chenghai BI Peiying JIANG Yimin WU Yiwei ZHANG Wei DONG Shen’an SANG Shibiao CHEN Weichang XU Fengpo WU Xinghong. Measurement of portal vein pressure by 99mTc-MIBI for the evaluation of the staging and therapeutic effect in cirrhosis[J]. Nuclear techniques, 2001, (11): 911-914. DOI:
采用99mTc -MIBI经直肠给药测定 5 4例肝硬化患者各组肝功能的心 /肝 (H/L)比值及门静脉压力 (PVP)
结果Child -A、B、C级各组H/L分别为 0 .4 9± 0 .18(2 1)、0 .6 9± 0 .16 (15 )、0 .91± 0 .2 1(18) ;PVP分别为 2 .2 2± 0 .5 7(2 1)kPa、2 .85± 0 .38(15 )kPa及 3.5 4± 0 .6 5 (18)kPa。而对照组的H/L及PVP分别为 0 .30± 0 .12 (16 )kPa及 1.6 1± 0 .384 6kPa。Child -A、B、C级各组分别与对照组及各组之间用t检验比较
除Child -B与C级组PVP无显著性差异 (P >0 .0 5 )外
其余均有非常显著性差异 (P <0 .0 0 1)及显著性差异 (P <0 .0 5 )。对 16例肝硬化患者治疗前后H/L及PVP进行测定
服药前、后H/L分别为 0 .73± 0 .16 (16 )及 0 .4 7± 0 .18(16 ) ;门脉压力分别为3.0 0± 0 .5 5 (16 )kPa及 2 .2 0± 0 .6 2 (16 )kPa
作配对t检验
结果治疗前后H/L及PVP差异非常显著。本法测定门脉压力方便
无创伤
病人能接受
而且可分析病情
判断疗效
对指导制订治疗方案
估计预后等均有独特价值
The heart/liver ratio (H/L) and portal vein pressure (PVP) in 54 patients of cirrhosis with various liver function were determined by the rectal administration of 99m Tc-MIBI
The H/L ratio in Child A (21 cases)
Child B (15 cases) and Child C (18 cases) group was 0.49±0.18
0.69±16 and 0.91±0.21 respectively
whereas the PVP was 2.22±0.57kPa
2.85±0.38kPa and 3.54±0.65kPa respectively. In normal controls (16 cases)
the H/L ratio and PVP was 0.30±0.12 and 1.61±0.38kPa. There was no significant difference in PVP between Child B and C groups
but has very significant ( P <0.001) and significant ( P <0.05) difference of H/L ratio and PVP in remaining groups after t test. In 16 cirrhotic patients the H/L ratio and PVP was 0.73±0.16 and 3.00±0.55 before treatment
and become 0.47±0.18 and 2.20±0.62kPa after treatment
there was also very significant difference after t-test. It was concluded that this method for the determination of PVP is not only convenient
but also atraumatic and acceptable for the patient. Thereby
it has unique value for the staging
monitoring therapeutic effect
guiding treatment protocol and jndging the prognosis etc. in cirrhotic patients.
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